TY - JOUR
T1 - Human papillomavirus infection, cervical cancer and the less explored role of trace elements
AU - Sravani, Anne Boyina
AU - Ghate, Vivek
AU - Lewis, Shaila
N1 - Funding Information:
The authors are grateful to the Indian Council of Medical Research (ICMR), Government of India for providing Senior Research Fellowship (SRF) to Anne Boyina Sravani [File No. 3/2/2/15/2020/NCD-III] and Manipal College of Pharmaceutical Sciences (MCOPS) and Manipal Academy of Higher Education (MAHE), Manipal, for their support in carrying out the literature search and access to databases.
Funding Information:
The authors are grateful to the Indian Council of Medical Research (ICMR), Government of India for providing Senior Research Fellowship (SRF) to Anne Boyina Sravani [File No. 3/2/2/15/2020/NCD-III] and Manipal College of Pharmaceutical Sciences (MCOPS) and Manipal Academy of Higher Education (MAHE), Manipal, for their support in carrying out the literature search and access to databases.
Publisher Copyright:
© 2022, The Author(s).
PY - 2023/3
Y1 - 2023/3
N2 - Cervical cancer is an aggressive type of cancer affecting women worldwide. Many affected individuals rely on smear tests for the diagnosis, surgery, chemotherapy, or radiation for their treatment. However, due to a broad set of undesired results and side-effects associated with the existing protocols, the search for better diagnostic and therapeutic interventions is a never-ending pursuit. In the purview, the bio-concentration of trace elements (copper, selenium, zinc, iron, arsenic, manganese, and cadmium) is seen to fluctuate during the occurrence of cervical cancer and its progression from pre-cancerous to metastatic nature. Thus, during the occurrence of cervical cancer, the detection of trace elements and their supplementation will prove to be highly advantageous in developing diagnostic tools and therapeutics, respectively. This review provides a detailed overview of cervical cancer, its encouragement by human papillomavirus infections, the mechanism of pathology, and resistance. Majorly, the review emphasizes the less explored role of trace elements, their contribution to the growth and inhibition of cervical cancer. Numerous clinical trials have been listed, thereby providing a comprehensive reference to the exploration of trace elements in the management of cervical cancer.
AB - Cervical cancer is an aggressive type of cancer affecting women worldwide. Many affected individuals rely on smear tests for the diagnosis, surgery, chemotherapy, or radiation for their treatment. However, due to a broad set of undesired results and side-effects associated with the existing protocols, the search for better diagnostic and therapeutic interventions is a never-ending pursuit. In the purview, the bio-concentration of trace elements (copper, selenium, zinc, iron, arsenic, manganese, and cadmium) is seen to fluctuate during the occurrence of cervical cancer and its progression from pre-cancerous to metastatic nature. Thus, during the occurrence of cervical cancer, the detection of trace elements and their supplementation will prove to be highly advantageous in developing diagnostic tools and therapeutics, respectively. This review provides a detailed overview of cervical cancer, its encouragement by human papillomavirus infections, the mechanism of pathology, and resistance. Majorly, the review emphasizes the less explored role of trace elements, their contribution to the growth and inhibition of cervical cancer. Numerous clinical trials have been listed, thereby providing a comprehensive reference to the exploration of trace elements in the management of cervical cancer.
UR - http://www.scopus.com/inward/record.url?scp=85128740093&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85128740093&partnerID=8YFLogxK
U2 - 10.1007/s12011-022-03226-2
DO - 10.1007/s12011-022-03226-2
M3 - Review article
C2 - 35467267
AN - SCOPUS:85128740093
SN - 0163-4984
VL - 201
SP - 1026
EP - 1050
JO - Biological Trace Element Research
JF - Biological Trace Element Research
IS - 3
ER -
