Hyperactivity of hypothalamic pituitary axis in neonatal clomipramine model of depression

J. Prathiba; K. B. Kumar; K. S. Karanth

doi:10.1007/s007020050135

Hyperactivity of hypothalamic pituitary axis in neonatal clomipramine model of depression

J. Prathiba, K. B. Kumar, K. S. Karanth

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39 Citations (Scopus)

Abstract

This study examined the integrity of hypothalamic-pituitary-adrenal (HPA) axis in clomipramine model of depression. Male rat pups were treated twice daily from postnatal day 5 to 21 with clomipramine (15 mg/kg, s.c.). At three months of age, serum corticosterone level was estimated before and after dexamethasone (100 μg/kg, s.c.) administration and after subjected to REM sleep deprivation (RSD) for 4 days consecutively. Data indicated enhanced baseline corticosterone levels and nonsuppression to dexamethasone in clomipramine treated rats. The corticosterone levels however, reversed to the levels of control group in rats subjected to RSD. These findings thus indicated for the first time an HPA hyperactivity in rats treated with clomipramine during neonatal period and are in harmony with cholinergic hypersensitivity reported earlier in this model of depression.

Original language	English
Pages (from-to)	1335-1339
Number of pages	5
Journal	Journal of Neural Transmission
Volume	105
Issue number	10-12
DOIs	https://doi.org/10.1007/s007020050135
Publication status	Published - 01-12-1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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title = "Hyperactivity of hypothalamic pituitary axis in neonatal clomipramine model of depression",

abstract = "This study examined the integrity of hypothalamic-pituitary-adrenal (HPA) axis in clomipramine model of depression. Male rat pups were treated twice daily from postnatal day 5 to 21 with clomipramine (15 mg/kg, s.c.). At three months of age, serum corticosterone level was estimated before and after dexamethasone (100 μg/kg, s.c.) administration and after subjected to REM sleep deprivation (RSD) for 4 days consecutively. Data indicated enhanced baseline corticosterone levels and nonsuppression to dexamethasone in clomipramine treated rats. The corticosterone levels however, reversed to the levels of control group in rats subjected to RSD. These findings thus indicated for the first time an HPA hyperactivity in rats treated with clomipramine during neonatal period and are in harmony with cholinergic hypersensitivity reported earlier in this model of depression.",

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AU - Kumar, K. B.

AU - Karanth, K. S.

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Hyperactivity of hypothalamic pituitary axis in neonatal clomipramine model of depression

Abstract

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