Hyponatraemia induced hyperCKaemia

A 32-year-old woman presented to Kasturba Hospital, Manipal with the features of gastroenteritis and one episode of generalised tonic clonic seizure with loss of consciousness for 5 min. No abnormalities were found during neurological examination. Her baseline investigations showed low sodium, low serum osmolality, normal renal and liver function tests, urine myoglobin and antinuclear antibodies profile were negative. Incidentally her creatine kinase (CK) levels were found to be very high. She was treated with intravenous fluids and high salt diet for hyponatraemia. With correction of hyponatraemia, CK levels also improved, suggesting the probable diagnosis of hyponatraemia induced myopathy leading to hyperCKaemia. The importance of early recognition of this potentially-dangerous and rare condition is emphasised.