TY - JOUR
T1 - Identification and evaluation of antioxidant, analgesic/anti-inflammatory activity of the most active ninhydrin-phenol adducts synthesized
AU - Prabhakar, K.R.
AU - Veerapur, V.P.
AU - Bansal, P.
AU - Vipan, K.P.
AU - Reddy, K.M.
AU - Barik, A.
AU - Reddy, B.K.D.
AU - Reddanna, P.
AU - Priyadarsini, K.I.
AU - Unnikrishnan, M.K.
N1 - Cited By :42
Export Date: 10 November 2017
CODEN: BMECE
Correspondence Address: Unnikrishnan, M.K.; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal, 576 104, India; email: [email protected]
Chemicals/CAS: lipoxygenase, 9027-17-2, 9029-60-1; ninhydrin, 17596-88-2, 2462-59-1, 485-47-2, 938-24-9; phenol, 108-95-2, 3229-70-7; prostaglandin synthase, 39391-18-9, 59763-19-8, 9055-65-6; Analgesics; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase Inhibitors; Free Radicals; Lipoxygenase Inhibitors; Ninhydrin, 485-47-2; Phenol, 108-95-2
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PY - 2006
Y1 - 2006
N2 - Treatment of phenols with ninhydrin in acidic medium afforded 2-hydroxy-2-(ortho-hydroxy-phenyl/naphthyl)-1,3-dioxoindanes, which being unstable were isolated in their hemiketal forms. These synthesized compounds were subjected to TLC screening for radical scavenging and in vitro lipoxgenase and cycloxygenase enzyme inhibition assays. The best compound was identified and studied in detail for steady-state and time-resolved free radical kinetics, viz., DPPH, ABTS{radical dot}-, {radical dot}OH and rate constants for these reactions were evaluated. The best compound was also subjected to in vivo anti-inflammatory and analgesic activities in which the compound showed good promise for further structural optimization. © 2006 Elsevier Ltd. All rights reserved.
AB - Treatment of phenols with ninhydrin in acidic medium afforded 2-hydroxy-2-(ortho-hydroxy-phenyl/naphthyl)-1,3-dioxoindanes, which being unstable were isolated in their hemiketal forms. These synthesized compounds were subjected to TLC screening for radical scavenging and in vitro lipoxgenase and cycloxygenase enzyme inhibition assays. The best compound was identified and studied in detail for steady-state and time-resolved free radical kinetics, viz., DPPH, ABTS{radical dot}-, {radical dot}OH and rate constants for these reactions were evaluated. The best compound was also subjected to in vivo anti-inflammatory and analgesic activities in which the compound showed good promise for further structural optimization. © 2006 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.bmc.2006.06.068
DO - 10.1016/j.bmc.2006.06.068
M3 - Article
SN - 0968-0896
VL - 14
SP - 7113
EP - 7120
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 21
ER -