Abstract
Delta-beta Thalassemia is a rare variant of thalassemia with elevated Hb F. Heterozygous and homozygous state of delta-beta thalassemia present with features similar to Hereditary Persistence of Fetal Haemoglobin (HPFH) and beta thalassemia intermedia. Here, we describe a case of 8-month-old female child with anaemia and splenomegaly. Haemoglobin electrophoresis showed 100% HbF and no HbA and HbA2. Patient was put on haematinics and advised a repeat haemoglobin electrophoresis after completion of 1 year of age, and family screening. Hb electrophoresis of the patient at the age of 2 years mirrored the earlier findings and her father, mother and brother showed increased Hb F with normal HbA2 levels. A final diagnosis of homozygous delta-beta thalassemia in the case with sibling and parents being heterozygous delta-beta thalassemia trait was rendered. Haemoglobin electrophoresis with red cell indices forms an important diagnostic clue in differentiating delta-beta thalassemia from other thalassemia syndromes.
Original language | English |
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Pages (from-to) | 88-93 |
Number of pages | 6 |
Journal | Journal of Krishna Institute of Medical Sciences University |
Volume | 9 |
Issue number | 2 |
Publication status | Published - 01-04-2020 |
All Science Journal Classification (ASJC) codes
- General Medicine