TY - JOUR
T1 - Immunomodulatory activities of Wrightia tinctoria (Roxb.) R. Br bark extracts
AU - Thabah, P.
AU - Murugananthan, G.
AU - Joshi, N.C.
AU - Nandakumar, K.
AU - Lakshman, K.
AU - Talwar, S.
N1 - Cited By :1
Export Date: 10 November 2017
Correspondence Address: Nandakumar, K.; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, 576 104, India; email: [email protected]
Chemicals/CAS: alcohol, 64-17-5; carbon, 7440-44-0; cyclophosphamide, 50-18-0; petroleum ether, 8032-32-4; water, 7732-18-5
Manufacturers: Cadila
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PY - 2009
Y1 - 2009
N2 - Wrightia tinctoria (Roxb.) R.Br. (WT) has been reported to exhibit number of therapeutic uses such as astringent, stomachic, febrifuge, skin diseases and tonic in India. The objective of the present study was to investigate the immunomodulatory activity of the bark extracts of WT using delayed type hypersensitivity reaction and carbon clearance assay. Powdered dried barks of WT were extracted with petroleum ether 60 - 80°C (PEWT), alcohol (ALWT) and aqueous alcohol (AQWT) (60% water + 40% ethanol) successively. PEWT and ALWT extracts (200,400mg/kg, p.o) produced a significant increase in delayed type hypersensitivity in response to sheep red blood cells (SRBC). PEWT showed better activity than ALWT in delayed type hypersensitivity response. ALWT (200 and 400mg/kg, p.o) in dose dependent manner have shown significantly increase in the phagocytic activity. The above results reveal that ALWT possesses immunostimulant activity in carbon clearance assay whereas PEWT and ALWT showed immunomodulatory activity in delayed type hypersensitivity model.
AB - Wrightia tinctoria (Roxb.) R.Br. (WT) has been reported to exhibit number of therapeutic uses such as astringent, stomachic, febrifuge, skin diseases and tonic in India. The objective of the present study was to investigate the immunomodulatory activity of the bark extracts of WT using delayed type hypersensitivity reaction and carbon clearance assay. Powdered dried barks of WT were extracted with petroleum ether 60 - 80°C (PEWT), alcohol (ALWT) and aqueous alcohol (AQWT) (60% water + 40% ethanol) successively. PEWT and ALWT extracts (200,400mg/kg, p.o) produced a significant increase in delayed type hypersensitivity in response to sheep red blood cells (SRBC). PEWT showed better activity than ALWT in delayed type hypersensitivity response. ALWT (200 and 400mg/kg, p.o) in dose dependent manner have shown significantly increase in the phagocytic activity. The above results reveal that ALWT possesses immunostimulant activity in carbon clearance assay whereas PEWT and ALWT showed immunomodulatory activity in delayed type hypersensitivity model.
M3 - Article
SN - 1827-8620
VL - 3
SP - 663
EP - 669
JO - Pharmacologyonline
JF - Pharmacologyonline
ER -