@article{4eb8600a3e7040979e8d1b18141e0f60,
title = "Immunomodulatory activities of Wrightia tinctoria (Roxb.) R. Br bark extracts",
abstract = "Wrightia tinctoria (Roxb.) R.Br. (WT) has been reported to exhibit number of therapeutic uses such as astringent, stomachic, febrifuge, skin diseases and tonic in India. The objective of the present study was to investigate the immunomodulatory activity of the bark extracts of WT using delayed type hypersensitivity reaction and carbon clearance assay. Powdered dried barks of WT were extracted with petroleum ether 60 - 80°C (PEWT), alcohol (ALWT) and aqueous alcohol (AQWT) (60% water + 40% ethanol) successively. PEWT and ALWT extracts (200,400mg/kg, p.o) produced a significant increase in delayed type hypersensitivity in response to sheep red blood cells (SRBC). PEWT showed better activity than ALWT in delayed type hypersensitivity response. ALWT (200 and 400mg/kg, p.o) in dose dependent manner have shown significantly increase in the phagocytic activity. The above results reveal that ALWT possesses immunostimulant activity in carbon clearance assay whereas PEWT and ALWT showed immunomodulatory activity in delayed type hypersensitivity model.",
author = "P. Thabah and G. Murugananthan and N.C. Joshi and K. Nandakumar and K. Lakshman and S. Talwar",
note = "Cited By :1 Export Date: 10 November 2017 Correspondence Address: Nandakumar, K.; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, 576 104, India; email: nandakumar77@rediffmail.com Chemicals/CAS: alcohol, 64-17-5; carbon, 7440-44-0; cyclophosphamide, 50-18-0; petroleum ether, 8032-32-4; water, 7732-18-5 Manufacturers: Cadila References: Orient L. Wrightia tinctoria (Roxb) R.Br. In Medicinal Plant, A Compendium of 500 species. Orient Longman Private Ltd 2004, Chennai, pp.417; Chatterjee, A., Chandrapatrashi, S., The treatise on Indian Medicinal Plants. Publication and information directorate (1995) New Delhi, p. 125; Jolly, C.I., Mechery, N.R., Comparative pharmacognostical, physicochemical and antibacterial studies on seeds of Holarrhena antidysenterica wall and Wrightia tinctoria R.Br (1996) Indian J Pharm Sci, 58, pp. 51-54; Krishnamoorthy, J.R., Ranganathan, S., Antipityrosporum ovale activity of a herbal drug combination of Wrightia tinctoria and Hisbiscus rosasinensis (2000) Indian J Dermatol, 45, pp. 125-126; Reddy, Y.S., Venkatesh, S., Ravichandran, T., Murugan, V., Suresh, B., Antinociceptive activity of Wrightia tinctoria bark (2002) Fitoterapia, 73 (5), pp. 421-423; Kumar, M.S., Srinivasan, K.K., Srinivasa, H., Veerapur, V.P., Palkar, M.B., Patra, S., The effect of ethanol extract of Wrightia tinctoria bark on wound healing in rats (2004) Journal of Natural Remedies, 4, pp. 155-159; Muruganandam, A.V., Bhattacharya, S.K., Ghosal, S., Indole and flavonoid constituents of Wrightia tinctoria, Wrightia tomentosa and Wrightia coccinea (2000) Indian J Chem, 39, pp. 125-131; Toshihiro, A., Ishtiaque, A., Sukhprit, S., Toshitake, T., Taro, M., Studies on Lipid 14α-Methyl zymosterol and other sterols from Wrightia tinctoria seeds (1988) Phytochemistry, 27, pp. 3231-3234; Kalavathy, K.R., Shetty, B.M.V., Ramachandran, Krishnamurthy, J.R., Effect of 777 oil on non- specific dermatitis (777 oil- a siddha herbal coded preparation) (1989) Journal of Research in Ayurveda and Siddha, 10, pp. 132-140; Roa, M.N., Roa, E.V., Roa, V.S., Triterpenoid components of the leaves and pods of Wrightia tinctoria (1966) Curr Sci, 35, pp. 518-519; Doherty, N.S., Selective effect of immunosuppressive agents against the delayed type hypersensitivity response and humoral response to sheep red blood cells in mice (1981) Agents action, 11, pp. 237-242; Pallabi, D., Dasgupta, S.C., Gomes, A., Immunopotentiating and immunoprophylactic activities of immune 21, a polyherbal product (1998) Indian J Pharmacol, 30, pp. 163-168; Xu, S.Y., Bian, R.L., Chen, X., (1982) Experimental Methods of Pharmacology, pp. 934-938. , People's Medical Publishing House, Beijing; Anonymous, C.S.I.R., (2002) The Wealth of India, p. 247. , National Institute of Science Communication, New Delhi; Descotes, J., (1999) An Introduction to Immunotoxicology, p. 235. , Taylor & Francis, London; Bach, J.F., The pharmacological and immunological basis for the use of immunosuppressive drugs (1976) Drugs, 11, pp. 1-3; Sugiura, H., Sugiura, H., Nishida, H., Inaba, R., Mirbod, S.M., Iwata, H., Effects of different duration of excercise on macrophage functions in mice (2001) J App Physiol, 90, pp. 789-784; White, C.J., Gallin, J.I., Phagocyte defects (1986) Clin Immunol Immunopathol, 40, pp. 50-61; Awaya, K., Phylogeny of reticuloendothelial system (1979) J Clin Exp Med, 111, pp. 107-113",
year = "2009",
language = "English",
volume = "3",
pages = "663--669",
journal = "Pharmacologyonline",
issn = "1827-8620",
publisher = "SILAE (Italo-Latin American Society of Ethnomedicine)",
}