TY - JOUR
T1 - Impact of di-(2-ethylhexyl) phthalate on the uterus of adult Wistar rats
AU - Somasundaram, D. B.
AU - Manokaran, K.
AU - Selvanesan, B. C.
AU - Bhaskaran, R. S.
N1 - Publisher Copyright:
© The Author(s) 2016.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Di-(2-ethylhexyl) phthalate (DEHP) is the most common plasticizer used in polyvinyl chloride-based plastics. DEHP is not covalently bound to the plastics and is easily released to the environment, resulting in human exposure. In this study, the adult rats were exposed to DEHP and its effects on the uterus was evaluated. Healthy adult female rats were treated with DEHP orally (with dose level 0, 1, 10, and 100 mg/kg body weight/day) for 30 days. No significant changes in the body weight and wet uterine weight were observed. Ovarian hormones and their receptor levels in the uterus were increased. Histological studies exhibited the structural abnormalities such as decrease in diameter, thinning of the layers and disruption in the glandular epithelium.
AB - Di-(2-ethylhexyl) phthalate (DEHP) is the most common plasticizer used in polyvinyl chloride-based plastics. DEHP is not covalently bound to the plastics and is easily released to the environment, resulting in human exposure. In this study, the adult rats were exposed to DEHP and its effects on the uterus was evaluated. Healthy adult female rats were treated with DEHP orally (with dose level 0, 1, 10, and 100 mg/kg body weight/day) for 30 days. No significant changes in the body weight and wet uterine weight were observed. Ovarian hormones and their receptor levels in the uterus were increased. Histological studies exhibited the structural abnormalities such as decrease in diameter, thinning of the layers and disruption in the glandular epithelium.
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U2 - 10.1177/0960327116657601
DO - 10.1177/0960327116657601
M3 - Article
C2 - 27473018
AN - SCOPUS:85019659731
SN - 0960-3271
VL - 36
SP - 565
EP - 572
JO - Human and Experimental Toxicology
JF - Human and Experimental Toxicology
IS - 6
ER -