TY - JOUR
T1 - Impact of serum 25 hydroxyvitamin D deficiency on lipid biomarkers in established coronary artery disease
AU - Yassir, Shaheena
AU - Ramarajan, Madan Gopal
AU - Patil, Seema
AU - Shaikh, Shaheen B.
AU - Abdulla, Yassir M.
AU - Manjrekar, Poornima A.
N1 - Funding Information:
Acknowledgments: Authors acknowledge Manipal Academy of Higher Education (award number - CK MU 274777) for financial assistance. This study was presented at Association of Medical Biochemist of India fourth State Conference – Telangana Chapter Research funding: This study was financially supported by Manipal Academy of Higher Education (award number - CK MU 274777). The funding agency had no involvement in the study’s design, data collection, analyzation, and interpretation, report writing, or judgement for submission and publication of article. Author contributions: None. Competing interests: There is no conflict of interest as declared by the authors. Declaration of patient consent: All participants provided written informed patient consent and were assured of their privacy and confidentiality.
Publisher Copyright:
© 2021 Shaheena Yassir et al.
PY - 2022/2
Y1 - 2022/2
N2 - Objectives: Vitamin D deficiency (VDD) is associated with coronary artery disease (CAD) directly by augmenting atherosclerosis and indirectly through cardiovascular risk factors. The present study was aimed to find an association of 25 hydroxyvitamin D (25(OH)D) with lipid profile among established CAD. Methods: A cross-sectional study was conducted among 73 patients of angiographically confirmed CAD aged between 35 and 55 years of both gender. Serum 25(OH)D and lipid profile were estimated by ELISA kit and Roche auto-analyzer respectively. Atherogenic index of plasma (AIP) and sdLDL (small dense low-density lipoprotein) were calculated using the accepted formula. Results: The mean 25(OH)D level was 17.95 ± 13.51. Only 15% had sufficient 25(OH)D level. There was a significant negative correlation of 25(OH)D with TC/HDL (T.cholesterol/High-density lipoprotein) ratio (p=0.022). Multivariate logistic regression analysis showed no statistically significant impact of 25(OH)D with lipid biomarkers. Conclusions: We found low 25(OH)D mean value among CAD and a significant negative correlation of 25(OH)D with TC/HDL. This study suggests VDD may affect primary lipid target resulting in unfavorable outcomes in CAD.
AB - Objectives: Vitamin D deficiency (VDD) is associated with coronary artery disease (CAD) directly by augmenting atherosclerosis and indirectly through cardiovascular risk factors. The present study was aimed to find an association of 25 hydroxyvitamin D (25(OH)D) with lipid profile among established CAD. Methods: A cross-sectional study was conducted among 73 patients of angiographically confirmed CAD aged between 35 and 55 years of both gender. Serum 25(OH)D and lipid profile were estimated by ELISA kit and Roche auto-analyzer respectively. Atherogenic index of plasma (AIP) and sdLDL (small dense low-density lipoprotein) were calculated using the accepted formula. Results: The mean 25(OH)D level was 17.95 ± 13.51. Only 15% had sufficient 25(OH)D level. There was a significant negative correlation of 25(OH)D with TC/HDL (T.cholesterol/High-density lipoprotein) ratio (p=0.022). Multivariate logistic regression analysis showed no statistically significant impact of 25(OH)D with lipid biomarkers. Conclusions: We found low 25(OH)D mean value among CAD and a significant negative correlation of 25(OH)D with TC/HDL. This study suggests VDD may affect primary lipid target resulting in unfavorable outcomes in CAD.
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U2 - 10.1515/tjb-2021-0148/html
DO - 10.1515/tjb-2021-0148/html
M3 - Article
AN - SCOPUS:85126313779
SN - 0250-4685
VL - 47
SP - 79
EP - 84
JO - Turkish Journal of Biochemistry
JF - Turkish Journal of Biochemistry
IS - 1
ER -