Abstract
Objective: To evaluate whether the extract of Ginkgo biloba (GB) could reverse the healing suppressant effect of Cyclophosphamide(CLP). Methods: The wound healing effects of CLP (12.6 mg/kg/ IP single dose on 3'd post wounding day) and GB (50 mg/kg IP) daily were tested on dead space and excision wound models in male rats. Results: CLP has significantly (p<0.05) reduced and GB has significantly (p<0.05) increased the breaking strength and hydroxyproline content of granulation tissue in dead space wounds. GB has significantly (p<0.01) reversed the suppressant effect of CLP. In case of excision wounds there was no change in wound contraction and epithelization period by CLP, GB or GB+CLP when compared to control. Conclusion: The healing suppressant effect of CLP was reversed by co-administration of GB. This effect of GB may due to its antioxidant property.
| Original language | English |
|---|---|
| Pages (from-to) | 31-34 |
| Number of pages | 4 |
| Journal | Journal of Natural Remedies |
| Volume | 6 |
| Issue number | 1 |
| Publication status | Published - 01-01-2006 |
All Science Journal Classification (ASJC) codes
- Pharmacology