In-silico and in-vivo evaluation of sesamol and its derivatives for benign prostatic hypertrophy

Abhishek Shah, Aarti Abhishek Shah, Krishnadas Nandakumar, Avinash Kumar, Aravinda Pai, Richard Lobo

Research output: Contribution to journalArticlepeer-review


Pharmacological treatment for BPH includes 5-α reductase inhibitors as Finasteride and Dutasteride as a monotherapy or in combination with antimuscarinic drugs, alpha-blockers, 5-phosphodiesterase inhibitor drugs. Androgen receptor inhibitors revealed several adverse events as decreased libido, erectile dysfunction, ejaculatory dysfunction, and gynecomastia. Hence, the emergence of complementary and alternative medications having safety profile—preferably, edible natural products—would be highly desirable. In-silico studies based on Maestro Molecular Modelling platform (version 10.5) by Schrӧdinger, LLC was used to identify the lead molecules. The in-vivo activity studied on rats gave the positive results. The findings based on experiments as antioxidant parameters showed the potential to quench the free radicals. The significant results were also seen in prostatic index and histopathological studies supported the above findings. Based on these data, sesamol and derivative have proven efficacy in protecting against testosterone induced BPH.

Original languageEnglish
Article number411
Journal3 Biotech
Issue number9
Publication statusPublished - 09-2021

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Environmental Science (miscellaneous)
  • Agricultural and Biological Sciences (miscellaneous)


Dive into the research topics of 'In-silico and in-vivo evaluation of sesamol and its derivatives for benign prostatic hypertrophy'. Together they form a unique fingerprint.

Cite this