@article{8dda4f46855044cfb14e949c21ffba1f,
title = "In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine",
abstract = "Berberine is a benzyl tetra isoquinoline alkaloid which is widely used as an antimicrobial and an antidiarrhoeal. As berberine containing plants are virtually used in all forms of traditional medicine, our study aimed to examine the antioxidant activity of berberine using 2,2-diphenyl 1-picrylhydrazyl (DPPH) radical scavenging, nitric oxide scavenging, lipid peroxidation, superoxide scavenging, iron chelating activity and 2,2-azino bis(3-ethylbenzothiazoline-6- sulfonate) (ABTS) radical scavenging methods. The IC50 values for all the models were calculated by regression analysis. In all the models tested, berberine showed its ability to scavenge the free radicals in a concentration dependent manner. The present study thereby justifies the therapeutic potential of berberine. {\textcopyright} 2006 Pharmaceutical Society of Japan.",
author = "A. Shirwaikar and K. Rajendran and I.S.R. Punitha",
note = "Cited By :134 Export Date: 10 November 2017 CODEN: BPBLE Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, 576 104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: 1,1 diphenyl 2 picrylhydrazyl, 1898-66-4; berberine, 2086-83-1, 633-65-8; nitric oxide, 10102-43-9; 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid, 28752-68-3; Antioxidants; Benzothiazoles; Berberine, 2086-83-1; Dimethyl Sulfoxide, 67-68-5; Free Radical Scavengers; Iron, 7439-89-6; Nitric Oxide, 10102-43-9; Sulfonic Acids; Superoxides, 11062-77-4 References: Amin, A.H., Subbaiah, T.V., Abbasi, K.M., (1969) Can. J. Micro. Biol., 15, pp. 1067-1076; Mahajan, V.M., Sharma, A., Rattan, A., (1982) Sabouraudia, 20, pp. 79-81; Subbaiah, T.V., Amin, A.H., (1967) Nature (London), 215, pp. 527-528; Gudima, S.O., Memelova, L.V., Borodulin, V.B., (1994) Mol. Biol., 28, pp. 1308-1314. , Mosk; Babbar, O.P., Chatwal, V.K., Ray, I.B., Henra, H.K., (1982) Ind. J. Med. Res., 76 (SUPPL.), pp. 83-88; Mohan, M., Pant, C.R., Angea, S.K., Mahajan, V.M., (1982) Ind. J. Ophthamol., 30, pp. 69-75; Sabir, M., Mahajan, V.M., Mohapatra, L.N., Bhide, N.K., (1976) Ind. J. Med. Res., 64, pp. 1160-1167; Taylor, C.T., Baird, A.W., (1995) Br. J. Pharmacol., 116, pp. 2667-2672; Akhter, M.H., Sabir, M., Bhide, N.K., (1979) Ind. J. Med. Res., 70, pp. 233-241; Xu, Z., Cao, H.Y., Li, Q., (1989) Chung. Kuo. Yao. Li. Hsueh. Pao., 10, pp. 320-324; Ckless, K., Schlottfeldt, J.L., Pasqual, M., (1995) J. Pharm. Pharmacol., 47, pp. 1029-1031; Wu, J.F., Liu, T.P., (1995) Yao. Hsueh. Hsueh. Pao., 30, pp. 98-102; Chan, M.Y., (1977) Comp. Med. East West, 5, pp. 161-168; Huang, W., (1990) Chung. Hua. Hsin. Hsueh. Kuan. Ping. Tsa. Chih., 18, pp. 231-234; Pan, G.-Y., Huang, Z.-J., Wang, G.-J., (2003) Planta Med., 69, pp. 632-636; Paul Dewick, M., (2002) {"}Medicinal Natural Products: A Biosynthetic Approach,{"} 2nd Ed., 1, pp. 315-344. , John Wiley & Sons, New York; Molyneux, P., (2004) Songklanakarin. J. Sci. Technol., 26, pp. 212-219; Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., Rice-Evans, C., (1998) Free Radic. Biol. Med., 72, pp. 1231-1237; Sreejayan, N., Rao, M.N.A., (1997) J. Pharm. Pharmacol., 49, pp. 105-107; Govindrarajan, R., Vijayakumar, M., Rawat, A.K.S., Mehrotra, S., (2003) Ind. J. Exp. Biol., 41, pp. 875-875; John, A., Steven, D.A., (1984) Methods Enzymol., 30, pp. 302-308; Benzie, I.F.F., Strain, J.T., (1996) Anal. Biochem., 239, pp. 70-76; Benzie, I.F.F., Szeto, Y.T., (1999) J. Agric. Food Chem., 47, pp. 633-636; Badmis, S., Gupta, M.K., Suresh, B., (2003) J. Ethno Pharmacol., 85, pp. 227-230; Long, L.H., Kwee, D.C., Halliwell, B., (2000) Free Radic. Res., 32, pp. 181-186; Govindarajan, R., Rastogi, S., Vijayakumar, M., Shirwaikar, A., Rawat, A.K.S., Mehrotra, S., Pushpangadan, P., (2003) Biol. Pharm. Bull., 26, pp. 1424-1427; Hicano, H., (1998) Foreign Med. Sci., 20, pp. 31-35; Luo, J.D., Chen, A.F., (2005) Acta Pharmacol. Sin., 26, pp. 259-264; Ma, L., Wallace, J.L., (2000) Am. J. Physiol. Gastrointest. Liver Physiol., 279, pp. 341-346; Lin, W.C., Chang, H.L., (1995) Res. Commun. Mol. Pathol. Pharmacol., 90, pp. 333-346; Lee, M.K., Kim, H.S., (1996) Planta Med., 62, pp. 31-34; Ckless, K., Schlottfeldt, J.L., Pasqual, M., (1995) J. Pharm. Pharmacol., 47, pp. 1029-1031; Wu, J.F., Liu, T.P., (1995) Yao. Hsueh. Hsueh. Pao., 30, pp. 98-102; Huang, C.G., Chu, Z.L., Yang, Z.M., (1991) Chung. Kuo. Yao. Li. Hsueh. Pao., 12, pp. 526-528; Cross, A.R., Jones, O.T.G., (1991) Biochem. Biophys. Acta, 387, pp. 281-285; Riccioppo Neto, F., (1993) Br. J. Pharmacol., 108, pp. 534-537; Harris, G.M., Livingstone, S.E., (1964) Chelating Agents and Metal Chelates, 1, p. 95. , ed. by Dwyer F. P., Mellor D. P., Academic Press, New York; Halliwell, B., (1991) Am. J. Med., 91, pp. 14-22; Gordon, M.H., (1990) Food Antioxidants, pp. 1-18. , ed. by Hudson B. J. F., Elsevier, London",
year = "2006",
doi = "10.1248/bpb.29.1906",
language = "English",
volume = "29",
pages = "1906--1910",
journal = "Biological and Pharmaceutical Bulletin",
issn = "0918-6158",
publisher = "Pharmaceutical Society of Japan",
number = "9",
}