TY - JOUR
T1 - In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine
AU - Shirwaikar, A.
AU - Rajendran, K.
AU - Punitha, I.S.R.
N1 - Cited By :134
Export Date: 10 November 2017
CODEN: BPBLE
Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, 576 104, India; email: [email protected]
Chemicals/CAS: 1,1 diphenyl 2 picrylhydrazyl, 1898-66-4; berberine, 2086-83-1, 633-65-8; nitric oxide, 10102-43-9; 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid, 28752-68-3; Antioxidants; Benzothiazoles; Berberine, 2086-83-1; Dimethyl Sulfoxide, 67-68-5; Free Radical Scavengers; Iron, 7439-89-6; Nitric Oxide, 10102-43-9; Sulfonic Acids; Superoxides, 11062-77-4
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PY - 2006
Y1 - 2006
N2 - Berberine is a benzyl tetra isoquinoline alkaloid which is widely used as an antimicrobial and an antidiarrhoeal. As berberine containing plants are virtually used in all forms of traditional medicine, our study aimed to examine the antioxidant activity of berberine using 2,2-diphenyl 1-picrylhydrazyl (DPPH) radical scavenging, nitric oxide scavenging, lipid peroxidation, superoxide scavenging, iron chelating activity and 2,2-azino bis(3-ethylbenzothiazoline-6- sulfonate) (ABTS) radical scavenging methods. The IC50 values for all the models were calculated by regression analysis. In all the models tested, berberine showed its ability to scavenge the free radicals in a concentration dependent manner. The present study thereby justifies the therapeutic potential of berberine. © 2006 Pharmaceutical Society of Japan.
AB - Berberine is a benzyl tetra isoquinoline alkaloid which is widely used as an antimicrobial and an antidiarrhoeal. As berberine containing plants are virtually used in all forms of traditional medicine, our study aimed to examine the antioxidant activity of berberine using 2,2-diphenyl 1-picrylhydrazyl (DPPH) radical scavenging, nitric oxide scavenging, lipid peroxidation, superoxide scavenging, iron chelating activity and 2,2-azino bis(3-ethylbenzothiazoline-6- sulfonate) (ABTS) radical scavenging methods. The IC50 values for all the models were calculated by regression analysis. In all the models tested, berberine showed its ability to scavenge the free radicals in a concentration dependent manner. The present study thereby justifies the therapeutic potential of berberine. © 2006 Pharmaceutical Society of Japan.
U2 - 10.1248/bpb.29.1906
DO - 10.1248/bpb.29.1906
M3 - Article
SN - 0918-6158
VL - 29
SP - 1906
EP - 1910
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
IS - 9
ER -