TY - JOUR
T1 - In vivo intra- and inter-individual variability study of human stratum corneum by confocal Raman spectroscopy
AU - dos Santos, Laurita
AU - Rangel, Joao Lucas
AU - Tippavajhala, Vamshi Krishna
AU - da Silva, Michely Glenda Pereira
AU - Mogilevych, Borys
AU - Martin, Airton Abrahão
PY - 2016/11/1
Y1 - 2016/11/1
N2 - The present research work deals with the in vivo determination of intra- and inter-individual human stratum corneum biochemical variability using confocal Raman spectroscopy. This study was carried out at three different spots on the volar forearm region of healthy human participants in the extended fingerprint and high wavenumber spectral regions. All the preprocessed spectra were compared by correlation matrices, which were calculated using Pearson's correlation coefficient (r). The results indicate that the participated volunteers in this study are homogenous with respect to the stratum corneum in the forearm region in both extended fingerprint and high wavenumber regions as there is high correlation between their Raman spectra at both intra- and inter-individual levels. This study confirms the application of confocal Raman spectroscopy as an accurate and precise technique for in vivo studies involving human skin.
AB - The present research work deals with the in vivo determination of intra- and inter-individual human stratum corneum biochemical variability using confocal Raman spectroscopy. This study was carried out at three different spots on the volar forearm region of healthy human participants in the extended fingerprint and high wavenumber spectral regions. All the preprocessed spectra were compared by correlation matrices, which were calculated using Pearson's correlation coefficient (r). The results indicate that the participated volunteers in this study are homogenous with respect to the stratum corneum in the forearm region in both extended fingerprint and high wavenumber regions as there is high correlation between their Raman spectra at both intra- and inter-individual levels. This study confirms the application of confocal Raman spectroscopy as an accurate and precise technique for in vivo studies involving human skin.
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U2 - 10.1016/j.vibspec.2016.10.007
DO - 10.1016/j.vibspec.2016.10.007
M3 - Article
AN - SCOPUS:84994029423
SN - 0924-2031
VL - 87
SP - 199
EP - 206
JO - Vibrational Spectroscopy
JF - Vibrational Spectroscopy
ER -