TY - JOUR
T1 - Indicators of oxidative stress in thyroid cancer
AU - Kodurua, Bhargav
AU - Tejaswinia,
AU - Thakura, Ajit
AU - Kamatha, Shobha U.
AU - Shenoy, Kallya Rajgopal
AU - Kamathc, Ullas
AU - Reshmad, K.
PY - 2010/4
Y1 - 2010/4
N2 - Ferric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity and the levels of protein thiols and carbonyls were estimated in the blood samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as well as in healthy controls (n = 10) to study the extent of damage caused by tumor tissue proliferation-induced oxidative stress and to ascertain that oxidative stress levels drop, when there was no proliferation. A significant decrease (p<0.001) in the levels of serum protein thiols and FRAP as well as a significant increase (p<0.001) in the levels of protein carbonyls and MPO activity in the blood of thyroid cancer patients before surgery was observed as compared to healthy controls. All the parameters studied also showed a significant difference (p<0.001) in their respective levels in thyroid cancer patients, preand post-thyroidectomy. These findings present the role of oxidative stress as a pathological implication of thyroid cancer.
AB - Ferric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity and the levels of protein thiols and carbonyls were estimated in the blood samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as well as in healthy controls (n = 10) to study the extent of damage caused by tumor tissue proliferation-induced oxidative stress and to ascertain that oxidative stress levels drop, when there was no proliferation. A significant decrease (p<0.001) in the levels of serum protein thiols and FRAP as well as a significant increase (p<0.001) in the levels of protein carbonyls and MPO activity in the blood of thyroid cancer patients before surgery was observed as compared to healthy controls. All the parameters studied also showed a significant difference (p<0.001) in their respective levels in thyroid cancer patients, preand post-thyroidectomy. These findings present the role of oxidative stress as a pathological implication of thyroid cancer.
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M3 - Article
C2 - 20521627
AN - SCOPUS:77954344640
SN - 0301-1208
VL - 47
SP - 121
EP - 123
JO - Annals of biochemistry and experimental medicine
JF - Annals of biochemistry and experimental medicine
IS - 2
ER -