TY - JOUR
T1 - Industrially scalable synthesis of anti-alzheimer drug donepezil
AU - Gaonkar, Santosh L.
AU - Nadaf, Y. F.
AU - Bilehal, Dinesh
AU - Shetty, Nitinkumar S.
PY - 2017
Y1 - 2017
N2 - This paper describes a simple, efficient and industrially scalable total synthesis of donepezil hydrochloride. The article also reported the X-ray studies of the 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyindan-1-one, an intermediate in the synthesis of donepezil. The crystal structure analysis of 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyindan-1-one shows that it crystallizes in monoclinic class under the space group P121/c1 with cell parameters, a = 17.2992(7) Å, b = 10.1999(4) Å, c = 11.9539(5) Å, β = 103.450(2)°, V = 2051.42(15) Å3 and Z = 4.
AB - This paper describes a simple, efficient and industrially scalable total synthesis of donepezil hydrochloride. The article also reported the X-ray studies of the 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyindan-1-one, an intermediate in the synthesis of donepezil. The crystal structure analysis of 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyindan-1-one shows that it crystallizes in monoclinic class under the space group P121/c1 with cell parameters, a = 17.2992(7) Å, b = 10.1999(4) Å, c = 11.9539(5) Å, β = 103.450(2)°, V = 2051.42(15) Å3 and Z = 4.
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U2 - 10.14233/ajchem.2017.20716
DO - 10.14233/ajchem.2017.20716
M3 - Article
AN - SCOPUS:85025450016
SN - 0970-7077
VL - 29
SP - 1999
EP - 2004
JO - Asian Journal of Chemistry
JF - Asian Journal of Chemistry
IS - 9
ER -