TY - JOUR
T1 - Inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate
T2 - Effect of pre-administration of α-tocopherol
AU - Prabhu, H. Ramachandra
AU - Nandini, M.
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Rats pre-administered with á-tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of á-tocopherol in the diethyldithiocarbamate treated rats may be attributed to its antioxidant/free radical scavenging action. It is concluded that selenium-dependent glutathione peroxidase and á-tocopherol act in a complementary fashion to block free radical formation.
AB - Rats pre-administered with á-tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of á-tocopherol in the diethyldithiocarbamate treated rats may be attributed to its antioxidant/free radical scavenging action. It is concluded that selenium-dependent glutathione peroxidase and á-tocopherol act in a complementary fashion to block free radical formation.
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M3 - Article
C2 - 17569290
AN - SCOPUS:34547824496
SN - 0019-5189
VL - 45
SP - 465
EP - 468
JO - Journal of scientific & industrial research. C. Biological sciences
JF - Journal of scientific & industrial research. C. Biological sciences
IS - 5
ER -