TY - JOUR
T1 - Insight into the impact of zinc doping on the structural, surface, and biological properties of magnasium oxide nanoparticles stabilized by Vateria indica (L.) fruit extract
AU - D'Souza, Josline Neetha
AU - Nagaraja, G. K.
AU - Meghana Navada, K.
AU - Kouser, Sabia
AU - Manasa, D. J.
N1 - Funding Information:
The coordinator of DST-PURSE, Mangalore University, and the vision group of science and technology (VGST- Karnataka government) are acknowledged for the instrumentation facility. JND is thankful to the Directorate of Minorities, Karnataka government for fellowship. The authors are grateful to Prof. Raju Krishna chalannavar, Department of Applied Botany, Mangalore University.
Publisher Copyright:
© 2021 Elsevier Ltd and Techna Group S.r.l.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - The present study is an attempt to delineate the effect of zinc doping on the green synthesized magnesium oxide (MgO) NPs. Pure (MgOVI) and zinc doped (ZnMgOVI) NPs were synthesized employing an aqueous fruit extract of V. indica as capping and reducing agents. The various analytical techniques viz. FTIR, PXRD, FESEM, and EDS spectroscopy together with elemental mapping analyses substantiated the formation of pure and doped NPs with crystallite sizes 23.74 and 25.41 nm. The study of surface properties through BET analysis unfolded the formation of mesoporous NPs with a surface area of 7.4 and 5.3 m2g-1 for pure and doped NPs respectively. Additionally, the refinement of obtained PXRD data through Rietveld refinement corroborated the changes in cell parameters after zinc doping. The anti-inflammatory activity carried out unveiled the biocompatibility of obtained NPs by exhibiting a % HRBCS of 83.65 ± 0.002 and 85.69 ± 0.003 for MgOVI and ZnMgOVI NPs. The in-vitro antidiabetic activity of MgOVI and ZnMgOVI NPs performed revealed their excellent α-amylase inhibition activity (86.29 ± 0.001and 86.44 ± 0.002%). Furthermore, the NPs also displayed anti-microbial activities against Staphylococcus aureus, Bacillus subtulis, Pseudomonas aeroginosa, Pseudomonas syringae, and Escherichia coli. Thus the studies have evinced the superlative antidiabetic and antimicrobial potentialities of MgOVI and ZnMgOVI NPs with high biocompatibility.
AB - The present study is an attempt to delineate the effect of zinc doping on the green synthesized magnesium oxide (MgO) NPs. Pure (MgOVI) and zinc doped (ZnMgOVI) NPs were synthesized employing an aqueous fruit extract of V. indica as capping and reducing agents. The various analytical techniques viz. FTIR, PXRD, FESEM, and EDS spectroscopy together with elemental mapping analyses substantiated the formation of pure and doped NPs with crystallite sizes 23.74 and 25.41 nm. The study of surface properties through BET analysis unfolded the formation of mesoporous NPs with a surface area of 7.4 and 5.3 m2g-1 for pure and doped NPs respectively. Additionally, the refinement of obtained PXRD data through Rietveld refinement corroborated the changes in cell parameters after zinc doping. The anti-inflammatory activity carried out unveiled the biocompatibility of obtained NPs by exhibiting a % HRBCS of 83.65 ± 0.002 and 85.69 ± 0.003 for MgOVI and ZnMgOVI NPs. The in-vitro antidiabetic activity of MgOVI and ZnMgOVI NPs performed revealed their excellent α-amylase inhibition activity (86.29 ± 0.001and 86.44 ± 0.002%). Furthermore, the NPs also displayed anti-microbial activities against Staphylococcus aureus, Bacillus subtulis, Pseudomonas aeroginosa, Pseudomonas syringae, and Escherichia coli. Thus the studies have evinced the superlative antidiabetic and antimicrobial potentialities of MgOVI and ZnMgOVI NPs with high biocompatibility.
UR - https://www.scopus.com/pages/publications/85111518105
UR - https://www.scopus.com/inward/citedby.url?scp=85111518105&partnerID=8YFLogxK
U2 - 10.1016/j.ceramint.2021.07.131
DO - 10.1016/j.ceramint.2021.07.131
M3 - Article
AN - SCOPUS:85111518105
SN - 0272-8842
VL - 47
SP - 29620
EP - 29630
JO - Ceramics International
JF - Ceramics International
IS - 21
ER -