TY - JOUR
T1 - Interactions of polyphenols with plasma proteins
T2 - Insights from analytical techniques
AU - Jaldappagari, Seetharamappa
AU - Balakrishnan, Sandhya
AU - Hegde, Ashwini H.
AU - Teradal, Nagappa L.
AU - Narayan, Prashanth S.
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Phenolic compounds are commonly found in natural sources like plant-based foods and beverages. These compounds have received much attention due to their unique biological properties. Polyphenols possess a significant binding affinity for serum albumins which are known to be principal extracellular proteins with a high concentration in blood plasma. They act as carriers of several drugs to different molecular targets. This review summarizes the salient features of the reported work on polyphenol-protein interactions by analytical methods viz., chromatography, circular dichroism, fluorescence spectroscopy (steady state and time resolved), light scattering, equilibrium dialysis, differential scanning calorimetry, UV-vis spectroscopy, isothermal calorimetry, MALDI-TOF mass spectrometry, size exclusion chromatography, capillary electrophoresis, electrospray ionization mass spectrometry, FT-IR, molecular modelling, HPLC, NMR, cyclic voltammetry etc. Polyphenol-serum albumin interaction studies assume significance from the view point of pharmacokinet-ics and pharmacodynamics.
AB - Phenolic compounds are commonly found in natural sources like plant-based foods and beverages. These compounds have received much attention due to their unique biological properties. Polyphenols possess a significant binding affinity for serum albumins which are known to be principal extracellular proteins with a high concentration in blood plasma. They act as carriers of several drugs to different molecular targets. This review summarizes the salient features of the reported work on polyphenol-protein interactions by analytical methods viz., chromatography, circular dichroism, fluorescence spectroscopy (steady state and time resolved), light scattering, equilibrium dialysis, differential scanning calorimetry, UV-vis spectroscopy, isothermal calorimetry, MALDI-TOF mass spectrometry, size exclusion chromatography, capillary electrophoresis, electrospray ionization mass spectrometry, FT-IR, molecular modelling, HPLC, NMR, cyclic voltammetry etc. Polyphenol-serum albumin interaction studies assume significance from the view point of pharmacokinet-ics and pharmacodynamics.
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U2 - 10.2174/1389200211314040009
DO - 10.2174/1389200211314040009
M3 - Article
C2 - 23330930
AN - SCOPUS:84881631635
SN - 1389-2002
VL - 14
SP - 456
EP - 473
JO - Current Drug Metabolism
JF - Current Drug Metabolism
IS - 4
ER -