TY - JOUR
T1 - Interleukin-6 in impaired fasting glucose
AU - Agarwal, Ashish
AU - Hegde, Anupama
AU - Yadav, Charu
AU - Ahmad, Afzal
AU - Manjrekar, Poornima A.
AU - Rukmini, M. S.
N1 - Publisher Copyright:
© 2018, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Prediabetes is associated with the features of metabolic syndrome and inflammation contributing directly to the pathogenesis of cardiovascular disease (CVD). This study was conducted to explore the utility of interleukin-6 (IL-6) in determining the risk of CVD in prediabetes. It involves estimation of IL-6 & insulin along with its correlation with insulin, fasting plasma glucose (FPG), Insulin resistance (IR) and physical measurements. Eighty subjects were grouped into 40 prediabetes and 40 normoglycemic on the basis of FPG values. The mean insulin, IL-6, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) and anthropometric measurements were found to be significantly higher (P <0.05) in prediabetes group. IL-6 had a significant correlation with fasting insulin (r = -0.413) and HOMA-IR (r = -0.413), but no correlation with FPG (r = -0.227) in the prediabetes group. IL-6 also showed a positive correlation with body mass index BMI(r = -0.339), waist circumference WC (r = -484) and waist-to-hip ratio WHR (r = -0.430). This study concludes that prediabetes is associated with inflammation, increasing the risk of CVD in these individuals.
AB - Prediabetes is associated with the features of metabolic syndrome and inflammation contributing directly to the pathogenesis of cardiovascular disease (CVD). This study was conducted to explore the utility of interleukin-6 (IL-6) in determining the risk of CVD in prediabetes. It involves estimation of IL-6 & insulin along with its correlation with insulin, fasting plasma glucose (FPG), Insulin resistance (IR) and physical measurements. Eighty subjects were grouped into 40 prediabetes and 40 normoglycemic on the basis of FPG values. The mean insulin, IL-6, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) and anthropometric measurements were found to be significantly higher (P <0.05) in prediabetes group. IL-6 had a significant correlation with fasting insulin (r = -0.413) and HOMA-IR (r = -0.413), but no correlation with FPG (r = -0.227) in the prediabetes group. IL-6 also showed a positive correlation with body mass index BMI(r = -0.339), waist circumference WC (r = -484) and waist-to-hip ratio WHR (r = -0.430). This study concludes that prediabetes is associated with inflammation, increasing the risk of CVD in these individuals.
UR - http://www.scopus.com/inward/record.url?scp=85061957588&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061957588&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85061957588
SN - 0301-1208
VL - 55
SP - 424
EP - 428
JO - Indian Journal of Biochemistry and Biophysics
JF - Indian Journal of Biochemistry and Biophysics
IS - 6
ER -