Intranasal gene therapy for the treatment of neurological disorders

Namdev Dhas, Tejal Mehta, Shilpa Sharma, Atul Garkal, Dattatray Yadav, Kartik Hariharan, Babeeta Shamjetshabam, Shubham Khot, Ritu Kudarha, Priyanka Bangar, Gajanan Arbade, Pratap Kalyankar

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


Complex nature of central nervous system (CNS) results in difficulty to pass the drug/gene through BBB in the treatment of neurological disorders. Significant advances in targeted gene delivery have opened up ways of treating several neurological disorders across a variety of diverse modalities ranging from exogenous expression to endogenous suppression of genes. Recent nanotechnology-based advances for improved delivery of gene sequences have centered on extremely specific polymer-based gene delivery, viral vector designs, and plasmid transfection nanoparticle-based therapies. This chapter inculcates various neurological disorders and current approaches for their treatment. It also includes different challenges for intranasal gene delivery to CNS and gene delivery modalities. The authors also concentrated on several ideal properties of nanomaterials for intranasal gene delivery and various strategies involved for efficient nose-to-brain gene delivery. The chapter also put forth various factors affecting gene transportation using various nanomaterials. Nanoparticle-based approaches for intranasal gene delivery with translational medicines in the treatment of neurological disorders were also included.

Original languageEnglish
Title of host publicationDirect Nose-to-Brain Drug Delivery
Subtitle of host publicationMechanism, Technological Advances, Applications, and Regulatory Updates
Number of pages37
ISBN (Electronic)9780128225226
Publication statusPublished - 01-01-2021

All Science Journal Classification (ASJC) codes

  • Economics, Econometrics and Finance(all)
  • Business, Management and Accounting(all)


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