TY - JOUR
T1 - Intraoral slow-releasing polymeric patches containing sodium fluoride and chlorhexidine
T2 - Development and evaluation
AU - Karuna, Yarmunja Mahabala
AU - Nayak, Anupama P.
AU - Pralhad, Swati
AU - Mutalik, Srinivas
AU - Padya, Bharath Singh
N1 - Funding Information:
The authors are thankful to the Manipal College of Pharmaceutical Sciences, Manipal, and Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, for providing necessary facilities and support. The authors are also thankful to the All India Council for Technical Education (AICTE), Government of India, New Delhi, for the National Doctoral Fellowship to Mr Bharath Singh Padya.
Publisher Copyright:
© 2020 Yarmunja Mahabala Karuna et al. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - Early childhood caries (ECC) has been considered to be at epidemic proportions in developing countries. There is a scientific consensus regarding the benefit of a constant supply of low levels of fluoride, especially at the biofilm/saliva/ tooth interface in preventing dental caries. The use of controlled and sustained delivery systems containing fluoride can be considered as an effective means of eradicating ECC in high-risk individuals. The use of chlorhexidine as an antimicrobial agent in combination with fluoride is beneficial (Naidu et al., 2016). Slow-releasing devices containing both fluoride and chlorhexidine do not exist as of now. Hence, the aim of the present study was to design a slow-release polymeric intraoral patch containing fluoride and chlorhexidine, and to evaluate the amount of medicament released over 20 days. Three slow-releasing patches were fabricated with different concentrations of gelatin to determine the maximum release of medicaments. Using in-vitro drug release studies it was observed that, out of three patches prepared with equal concentrations of chlorhexidine (80 mg) and sodium fluoride (288 mg), a patch I containing 1,000 mg of gelatin was found to be beneficial for a sustained release of both medicaments.
AB - Early childhood caries (ECC) has been considered to be at epidemic proportions in developing countries. There is a scientific consensus regarding the benefit of a constant supply of low levels of fluoride, especially at the biofilm/saliva/ tooth interface in preventing dental caries. The use of controlled and sustained delivery systems containing fluoride can be considered as an effective means of eradicating ECC in high-risk individuals. The use of chlorhexidine as an antimicrobial agent in combination with fluoride is beneficial (Naidu et al., 2016). Slow-releasing devices containing both fluoride and chlorhexidine do not exist as of now. Hence, the aim of the present study was to design a slow-release polymeric intraoral patch containing fluoride and chlorhexidine, and to evaluate the amount of medicament released over 20 days. Three slow-releasing patches were fabricated with different concentrations of gelatin to determine the maximum release of medicaments. Using in-vitro drug release studies it was observed that, out of three patches prepared with equal concentrations of chlorhexidine (80 mg) and sodium fluoride (288 mg), a patch I containing 1,000 mg of gelatin was found to be beneficial for a sustained release of both medicaments.
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U2 - 10.7324/JAPS.2020.10103
DO - 10.7324/JAPS.2020.10103
M3 - Article
AN - SCOPUS:85096180983
SN - 2231-3354
VL - 10
SP - 30
EP - 35
JO - Journal of Applied Pharmaceutical Science
JF - Journal of Applied Pharmaceutical Science
IS - 10
ER -