Investigating the effect of chitosan's degree of deacetylation on size of the nanoparticle

Fiona C. Rodrigues, N. G. Devi, K. B. Koteshwara, Goutam Thakur

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1 Citation (Scopus)


Chitosan (CS) is a naturalcationic polysaccharide obtained by deacetylation of chitin, a biopolymer found mainly in the exoskeleton of crab, shrimp shells, etc. The chitosan degree of deacetylation (DD) is an important factor which determines some of the physiochemical and biological properties of chitosan. The present study focuses on evaluating the effect of chitosan DD on nanoparticle size by using three different DD of chitosan, i.e., 85%, 90% and 93%. Chitosan nanoparticles were prepared by ionic gelation method using sodium tripolyphosphate (TPP) as crosslinker. The particle size and polydispersity index (PDI) was studied using Dynamic Light Scattering (DLS) and was further characterized by Fourier Transform Infrared spectroscopy (FTIR) to confirm the interactions between the ammonium groups of CS and tripolyphosphoric groups of TPP in the prepared nanoparticles. The results demonstrated that nanoparticles prepared using 85% DD chitosan had an average particle size of 100.2 0.5 nm.

Original languageEnglish
Article number012109
JournalIOP Conference Series: Materials Science and Engineering
Issue number1
Publication statusPublished - 26-06-2020
Event2nd International Conference on Materials Science and Manufacturing Technology 2020, ICMSMT 2020 - Coimbatore, Tamil Nadu, India
Duration: 09-04-202010-04-2020

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)


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