TY - JOUR
T1 - Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-Induced inflammatory bowel disorder in albino rats
AU - Kondamudi, P. K.
AU - Kovelamudi, Hemalatha
AU - Mathew, Geetha
AU - Nayak, Pawan G.
AU - Rao, Mallikarjuna C.
AU - Shenoy, Rekha R.
PY - 2014
Y1 - 2014
N2 - Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods.The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results. The levels of MPO, TBARS, and tissue nitrite increased significantly ( < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Conclusions.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.
AB - Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods.The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results. The levels of MPO, TBARS, and tissue nitrite increased significantly ( < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Conclusions.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.
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U2 - 10.1155/2014/802701
DO - 10.1155/2014/802701
M3 - Article
C2 - 24616646
AN - SCOPUS:84898871367
SN - 2356-6140
VL - 2014
JO - The Scientific World Journal
JF - The Scientific World Journal
M1 - 673248
ER -