Irregular solution behaviour of paracetamol in binary solvents

C.V.S. Subrahmanyam; M. Sreenivasa Reddy; J. Venkata Rao; P. Gundu Rao

doi:10.1016/0378-5173(92)90350-B

Irregular solution behaviour of paracetamol in binary solvents

C.V.S. Subrahmanyam, M. Sreenivasa Reddy, J. Venkata Rao, P. Gundu Rao

Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

The irregular solution behaviour of paracetamol was observed in two solvent systems: ethyl acetate-methanol; water and normal alcohols. The extended Hildebrand solubility approach was used to process the solubility data on paracetamol. The solubility parameter of paracetamol was determined from different methods of data analysis and found to be approx. 13.40 H. The parameters W and (log γ2)/A were regressed against a polynomial of δ1 of the binary mixture. The expressions allowed calculation of the mole fraction solubility of paracetamol in polar solvents. The expression for W regression was satisfactory for the determination of the solubility of paracetamol in methanol, ethanol and their mixtures, but deviated in the case of butanol and propanol. © 1992.

Original language	Undefined/Unknown
Pages (from-to)	17-24
Number of pages	8
Journal	International Journal of Pharmaceutics
Volume	78
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-5173(92)90350-B
Publication status	Published - 1992

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Cite this

@article{4dfe5c5e5038445e81d99ab593b92a85,

title = "Irregular solution behaviour of paracetamol in binary solvents",

abstract = "The irregular solution behaviour of paracetamol was observed in two solvent systems: ethyl acetate-methanol; water and normal alcohols. The extended Hildebrand solubility approach was used to process the solubility data on paracetamol. The solubility parameter of paracetamol was determined from different methods of data analysis and found to be approx. 13.40 H. The parameters W and (log γ2)/A were regressed against a polynomial of δ1 of the binary mixture. The expressions allowed calculation of the mole fraction solubility of paracetamol in polar solvents. The expression for W regression was satisfactory for the determination of the solubility of paracetamol in methanol, ethanol and their mixtures, but deviated in the case of butanol and propanol. {\textcopyright} 1992.",

author = "C.V.S. Subrahmanyam and \{Sreenivasa Reddy\}, M. and \{Venkata Rao\}, J. and \{Gundu Rao\}, P.",

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TY - JOUR

T1 - Irregular solution behaviour of paracetamol in binary solvents

AU - Subrahmanyam, C.V.S.

AU - Sreenivasa Reddy, M.

AU - Venkata Rao, J.

AU - Gundu Rao, P.

N1 - cited By 31

PY - 1992

Y1 - 1992

N2 - The irregular solution behaviour of paracetamol was observed in two solvent systems: ethyl acetate-methanol; water and normal alcohols. The extended Hildebrand solubility approach was used to process the solubility data on paracetamol. The solubility parameter of paracetamol was determined from different methods of data analysis and found to be approx. 13.40 H. The parameters W and (log γ2)/A were regressed against a polynomial of δ1 of the binary mixture. The expressions allowed calculation of the mole fraction solubility of paracetamol in polar solvents. The expression for W regression was satisfactory for the determination of the solubility of paracetamol in methanol, ethanol and their mixtures, but deviated in the case of butanol and propanol. © 1992.

AB - The irregular solution behaviour of paracetamol was observed in two solvent systems: ethyl acetate-methanol; water and normal alcohols. The extended Hildebrand solubility approach was used to process the solubility data on paracetamol. The solubility parameter of paracetamol was determined from different methods of data analysis and found to be approx. 13.40 H. The parameters W and (log γ2)/A were regressed against a polynomial of δ1 of the binary mixture. The expressions allowed calculation of the mole fraction solubility of paracetamol in polar solvents. The expression for W regression was satisfactory for the determination of the solubility of paracetamol in methanol, ethanol and their mixtures, but deviated in the case of butanol and propanol. © 1992.

U2 - 10.1016/0378-5173(92)90350-B

DO - 10.1016/0378-5173(92)90350-B

M3 - Article

SN - 0378-5173

VL - 78

SP - 17

EP - 24

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-3

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