Is clonidine useful for treatment of clozapine-induced sialorrhea?

Samir Kumar Praharaj, Pankaj Verm, Dipaya Roy, Anuradha Singh

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Clozapine has shown superior efficacy in treatment of refractory schizophrenia, but its use is limited by emergent side-effects. Among other adverse effects, sialorrhea is a troublesome side-effect, its stigmatizing nature results in poor treatment compliance. Several hypotheses have been put forward in the etiology of clozapine-induced sialorrhea. α2 adrenergic antagonism is hypothesized to be involved in its pathophysiology, based on the response to clonidine and lofexidine. Oral clonidine (50 to 100 μg/day) was tried on 12 stable outpatients of schizophrenia maintained on clozapine. Wet area over the pillow as reported by the patients was recorded at baseline and at 4 weeks of treatment along with the subjective response after the treatment. Most of the patients reported a decrease in sialorrhea without any adverse events. We describe encouraging results in an open case series of oral clonidine for clozapine-induced sialorrhea.

Original languageEnglish
Pages (from-to)426-428
Number of pages3
JournalJournal of Psychopharmacology
Issue number4
Publication statusPublished - 01-07-2005

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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