TY - JOUR
T1 - Isolation, Detection and Analysis of Circulating Tumour Cells
T2 - A Nanotechnological Bioscope
AU - Das, Upama
AU - Banik, Soumyabrata
AU - Nadumane, Sharmila Sajankila
AU - Chakrabarti, Shweta
AU - Gopal, Dharshini
AU - Kabekkodu, Shama Prasada
AU - Srisungsitthisunti, Pornsak
AU - Mazumder, Nirmal
AU - Biswas, Rajib
N1 - Funding Information:
N.M. thanks the Department of Science and Technology (DST) (Project Number- SERB/MTR/2020/000058), and Indian Council of Medical Research (ICMR), (Project Number-ITR/Ad-hoc/43/2020-21, ID No. 2020-3286) Government of India, India for financial support. UD would like to acknowledge DST for providing financial support in form of DST INSPIRE Fellowship.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/1
Y1 - 2023/1
N2 - Cancer is one of the dreaded diseases to which a sizeable proportion of the population succumbs every year. Despite the tremendous growth of the health sector, spanning diagnostics to treatment, early diagnosis is still in its infancy. In this regard, circulating tumour cells (CTCs) have of late grabbed the attention of researchers in the detection of metastasis and there has been a huge surge in the surrounding research activities. Acting as a biomarker, CTCs prove beneficial in a variety of aspects. Nanomaterial-based strategies have been devised to have a tremendous impact on the early and rapid examination of tumor cells. This review provides a panoramic overview of the different nanotechnological methodologies employed along with the pharmaceutical purview of cancer. Initiating from fundamentals, the recent nanotechnological developments toward the detection, isolation, and analysis of CTCs are comprehensively delineated. The review also includes state-of-the-art implementations of nanotechnological advances in the enumeration of CTCs, along with future challenges and recommendations thereof.
AB - Cancer is one of the dreaded diseases to which a sizeable proportion of the population succumbs every year. Despite the tremendous growth of the health sector, spanning diagnostics to treatment, early diagnosis is still in its infancy. In this regard, circulating tumour cells (CTCs) have of late grabbed the attention of researchers in the detection of metastasis and there has been a huge surge in the surrounding research activities. Acting as a biomarker, CTCs prove beneficial in a variety of aspects. Nanomaterial-based strategies have been devised to have a tremendous impact on the early and rapid examination of tumor cells. This review provides a panoramic overview of the different nanotechnological methodologies employed along with the pharmaceutical purview of cancer. Initiating from fundamentals, the recent nanotechnological developments toward the detection, isolation, and analysis of CTCs are comprehensively delineated. The review also includes state-of-the-art implementations of nanotechnological advances in the enumeration of CTCs, along with future challenges and recommendations thereof.
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U2 - 10.3390/pharmaceutics15010280
DO - 10.3390/pharmaceutics15010280
M3 - Review article
AN - SCOPUS:85146628780
SN - 1999-4923
VL - 15
JO - Pharmaceutics
JF - Pharmaceutics
IS - 1
M1 - 280
ER -
