Kinetics and tissue distribution of niosomal bleomycin in tumor bearing mice

Bleomycin was encapsulated in niosomes and administered to tumor bearing mice. The plasma kinetics and tissue distribution of niosomal bleomycin was studied in tumor bearing mice. The niosome encapsulated bleomycin was cleared from the plasma much more slowly than was the free drug. A significant increase in plasma concentration of bleomycin was achieved in mice when it was administered as niosomes as compared to free drug. The tumor bleomycin level enhanced significantly.