Langerhans Cell Histiocytosis Presenting With Cardiac Tamponade: A Case Report

Kumaresh Hariram Jeyaraman, Ashwal Adamane Jayaram, Sudhakar M. Rao, Abdul Razak Uddina Kumeri, Krishnanand Nayak, Umesh Pai, Harsha M. Sagar

Research output: Contribution to journalArticlepeer-review


Background: Langerhans cell histiocytosis (LCH) is a rare disorder of the reticuloendothelial system with an unknown etiology. We herein present an LCH case with cardiac tamponade and the oral cavity involvement to raise awareness of the distinguishing features of this diagnostically challenging entity. Case Report: This study describes a 52-year-old man who presented with dyspnea (NYHA functional class II) and bilateral pedal edema of 4 days’ duration. A clinical examination revealed a large pericardial effusion with cardiac tamponade. A positron emission tomography-computed tomography scan showed a heterogeneously enhancing soft tissue lesion, 2.6×1.7×1.6 cm in size, in the right mid-submandibular region. An intraoral examination confirmed the right submandibular mass. The biopsy of the submandibular gland mass confirmed the diagnosis of LCH. Conclusions: LCH is often diagnosed in childhood but may manifest in any age group, from infancy to adulthood. Pericardial effusion is a rare finding in this case of LCH. The rarity and the variable system involvement of LCH necessitate a multidisciplinary approach for accurate diagnosis and effective treatment.

Original languageEnglish
Pages (from-to)142-149
Number of pages8
JournalIranian Heart Journal
Issue number2
Publication statusPublished - 04-2022

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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