Lipid peroxidation inhibition and anti-anoxie property of 1-phenyl-3-(4-hydroxy-3, 5-ditertbutylphenyl), prop-2-en-1-one

A Phenyl Styryl ketone, with sterically hindered phenolic group, 1-phenyl-3-(4-hydroxy-3,5-ditertbutyiphenyl), prop-2-en-1-one (PHP) was evaluated as in vitro inhibitor of iron-ascorbate stimulated lipid peroxidation in rat brain homogenates. It was found to be more potent than the standard antioxidant vitamin E. Further PHP was evaluated for its effect in vivo against nitrogen-induced anoxia. The test compound protected the mice significantly against nitrogen-induced anoxia.