TY - JOUR
T1 - Liposomes as versatile platform for cancer theranostics
T2 - Therapy, bio-imaging, and toxicological aspects
AU - Mehta, Swapnil
AU - Kulkarni, Sanjay
AU - Nikam, Ajinkya N.
AU - Padya, Bharat S.
AU - Pandey, Abhijeet
AU - Mutalik, Srinivas
N1 - Funding Information:
The authors are thankful to i) Manipal Academy of Higher Education (MAHE), Manipal, India (for Postdoctoral Fellowship provided to Dr. Abhijeet Pandey), ii) Stempeutics Research Private Limited Bangalore (for Junior Research Fellowship given to San-jay Kulkarni), iii) Themis Medicare Limited, Mumbai (for Junior Research Fellowship provided to Ajinkya N Nikam), iv) All India Council for Technical Education (AICTE), Government of India, New Delhi (for National Doctoral Fellowship given to Bharath S Padya). The authors are grateful to Manipal College of Pharmaceutical Sciences, MAHE, Manipal, India for providing the necessary facilities.
Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021/6
Y1 - 2021/6
N2 - Liposomes are nano-sized formulations having the benefits of site-specificity, biocompatibility, and biodegradability, which make them useful for the therapy and diagnosis of major diseases like cancer. In this review, various synthetic strategies of liposomes and their biomedical application in special concern to cancer are discussed. In context to the biomedical application, this article gives a detailed insight into subcellular targeted therapy and several therapeutic modifications like immunotherapy, receptor-based therapy, phototherapy, and combination therapy. The review also describes the liposome-based imaging platforms and the toxicity associated with liposomes. Owing to a significant amount of benefits of this carrier system, several products have been approved to be launched in the market and several others have already been marketed for clinical use.
AB - Liposomes are nano-sized formulations having the benefits of site-specificity, biocompatibility, and biodegradability, which make them useful for the therapy and diagnosis of major diseases like cancer. In this review, various synthetic strategies of liposomes and their biomedical application in special concern to cancer are discussed. In context to the biomedical application, this article gives a detailed insight into subcellular targeted therapy and several therapeutic modifications like immunotherapy, receptor-based therapy, phototherapy, and combination therapy. The review also describes the liposome-based imaging platforms and the toxicity associated with liposomes. Owing to a significant amount of benefits of this carrier system, several products have been approved to be launched in the market and several others have already been marketed for clinical use.
UR - http://www.scopus.com/inward/record.url?scp=85108109902&partnerID=8YFLogxK
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U2 - 10.2174/1381612827666210311142100
DO - 10.2174/1381612827666210311142100
M3 - Review article
C2 - 33719968
AN - SCOPUS:85108109902
SN - 1381-6128
VL - 27
SP - 1977
EP - 1991
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 17
ER -
