Lacidipine (LCDP), a BCS class II calcium channel blocker, is used as antihypertensive agent. LCDP possesses low aqueous solubility and also undergoes extensive first pass metabolism resulting in oral bioavailability of 10%. The present study was aimed to enhance the solubility and hence dissolution rate of LCDP by formulating into liquisolid compacts. LCDP liquisolid compacts were formulated using avicel PH 102, tween 80, aerosil 200 and sodium starch glycolate. A mathematical model was adopted to determine the suitable quantity of carrier and coating materials. The formulated tablets were evaluated for post compression parameters. Liquisolid tablets showed high drug release as compared to the pure drug. The optimized formulation exhibited 99.89 ± 0.162% of drug release within 45 min. Stability studies confirmed the stability of optimized formulation. Present study thus concluded that the liquisolid is a favourable technique to improve the solubility and drug release of LCDP.
|Number of pages
|Latin American Journal of Pharmacy
|Published - 01-01-2018
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Drug Discovery