TY - JOUR
T1 - Local drug delivery systems in the management of periodontitis
T2 - A scientific review
AU - H.R., Rajeshwari
AU - Dhamecha, Dinesh
AU - Jagwani, Satveer
AU - Rao, Meghana
AU - Jadhav, K.
AU - Shaikh, Shabana
AU - Puzhankara, Lakshmi
AU - Jalalpure, S.
PY - 2019/8/10
Y1 - 2019/8/10
N2 - Periodontitis (PD) is a microbial disease of tooth supporting tissues that results in progressive destruction of surrounding soft and hard tissues with eventual tooth mobility and exfoliation. Perioceutics, which includes the delivery of therapeutic agents via systemic and local means as an adjunct to mechanical therapy has revolutionized the arena of periodontal therapy. Selection of a right antimicrobial agent with appropriate route of drug administration is the key to successful periodontal therapy. Irrigating systems, fibers, gels, strips, films, microparticles, nanoparticles and low dose antimicrobial agents are some of the local drug delivery systems (LDDS) available in the field, which aims to deliver antimicrobial agents to sub-gingival diseased sites with minimal or no side-effects on other body sites. The present review aim to summarize the current state-of-the-art technology on LDDS in periodontal therapy ensuring the the practitioners are able to choose LDD agents which are custom made for a specific clinical condition.
AB - Periodontitis (PD) is a microbial disease of tooth supporting tissues that results in progressive destruction of surrounding soft and hard tissues with eventual tooth mobility and exfoliation. Perioceutics, which includes the delivery of therapeutic agents via systemic and local means as an adjunct to mechanical therapy has revolutionized the arena of periodontal therapy. Selection of a right antimicrobial agent with appropriate route of drug administration is the key to successful periodontal therapy. Irrigating systems, fibers, gels, strips, films, microparticles, nanoparticles and low dose antimicrobial agents are some of the local drug delivery systems (LDDS) available in the field, which aims to deliver antimicrobial agents to sub-gingival diseased sites with minimal or no side-effects on other body sites. The present review aim to summarize the current state-of-the-art technology on LDDS in periodontal therapy ensuring the the practitioners are able to choose LDD agents which are custom made for a specific clinical condition.
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U2 - 10.1016/j.jconrel.2019.06.038
DO - 10.1016/j.jconrel.2019.06.038
M3 - Review article
C2 - 31255689
AN - SCOPUS:85069557385
SN - 0168-3659
VL - 307
SP - 393
EP - 409
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -