TY - JOUR
T1 - Low leucocyte, neutrophil and lymphocyte count (tri-low phenotype) in melioidosis
T2 - A predictor of early mortality
AU - Gupta, Nitin
AU - Tirlangi, Praveen Kumar
AU - Ravindra, Prithvishree
AU - Bhat, Rachana
AU - Gupta, Mukund
AU - Boodman, Carl
AU - Rashid, Adil
AU - Mukhopadhyay, Chiranjay
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/1
Y1 - 2024/1
N2 - Introduction: Melioidosis is a bacterial disease caused by Burkholderia pseudomallei, a gram-negative bacillus endemic to parts of Asia and Northern Australia. This study aimed to identify the role of total and differential leucocyte count in predicting 48-h mortality in patients with melioidosis. Methodology: This retrospective cohort study included patients diagnosed with culture-proven melioidosis at Kasturba Medical College between 2017 and 2023. Total leucocyte count (TLC), absolute neutrophil count (ANC), and absolute lymphocytic count (ALC) were classified into low (first quartile), medium (second and third quartile) and high (last quartile). The chi-square test was used to compare each group's early (48-h) mortality. Results: Of the 170 patients with culture-confirmed melioidosis, 24 patients died within 48 h. The mortality was significantly higher in those with low TLC, ANC and ALC. When all three parameters were found to be low (tri-low phenotype), the specificity in predicting mortality was 93.2 %. Conclusion: Low TLC, ANC and ALC are significant predictors of mortality among melioidosis patients. There is a need to explore new strategies to improve clinical outcomes among melioidosis patients with tri-low phenotype.
AB - Introduction: Melioidosis is a bacterial disease caused by Burkholderia pseudomallei, a gram-negative bacillus endemic to parts of Asia and Northern Australia. This study aimed to identify the role of total and differential leucocyte count in predicting 48-h mortality in patients with melioidosis. Methodology: This retrospective cohort study included patients diagnosed with culture-proven melioidosis at Kasturba Medical College between 2017 and 2023. Total leucocyte count (TLC), absolute neutrophil count (ANC), and absolute lymphocytic count (ALC) were classified into low (first quartile), medium (second and third quartile) and high (last quartile). The chi-square test was used to compare each group's early (48-h) mortality. Results: Of the 170 patients with culture-confirmed melioidosis, 24 patients died within 48 h. The mortality was significantly higher in those with low TLC, ANC and ALC. When all three parameters were found to be low (tri-low phenotype), the specificity in predicting mortality was 93.2 %. Conclusion: Low TLC, ANC and ALC are significant predictors of mortality among melioidosis patients. There is a need to explore new strategies to improve clinical outcomes among melioidosis patients with tri-low phenotype.
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U2 - 10.1016/j.crmicr.2024.100303
DO - 10.1016/j.crmicr.2024.100303
M3 - Article
AN - SCOPUS:85208238821
SN - 2666-5174
VL - 7
JO - Current Research in Microbial Sciences
JF - Current Research in Microbial Sciences
M1 - 100303
ER -