Lung-on-chip: Its current and future perspective on pharmaceutical and biomedical applications

Angana De, Shatabdi Paul, Yeddula Nikhileshwar Reddy, Vaibhav Sharma, Jayeeta Bhaumik, Vamshi Krishna Tippavajhala

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Organ-on-a-chip is a three-dimensional microfluidic system that simulates the cellular structure and biological milieu of an organ, that seemed to be constructed and studied substantially in the last decade. Microchips can be configured to suit disease states in a variety of organs, including the lung. When contrasted to traditional in vitro models like monolayer cell lineages, lung-on-a-chip models lays out a pragmatic portrayal of disease pathophysiology and pharmaceuticals’ mode of action, and this is especially more prevailing in connection with the COVID-19 pandemic. Animal models have typically been used in pharmaceutical drug screening to assess pharmacological and toxicological reactions to a new entity. These adaptations, on the other hand, do not precisely represent biological reactions in humans. Present and prospective uses of the lung-on-a-chip model in the pulmonary system are highlighted in this overview. In addition, the constraints of existing in vitro systems for respiratory disease simulation and therapeutic discovery would be emphasized. Attributes of lung-on-a-chip transformative features in biomedical applications will be addressed to illustrate the relevance of this lung-on-chip model for medical science.

Original languageEnglish
Article number103930
JournalJournal of Drug Delivery Science and Technology
Publication statusPublished - 12-2022

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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