TY - JOUR
T1 - Lymphatic drug transport and associated drug delivery technologies
T2 - A comprehensive review
AU - Punjabi, Manjot S.
AU - Naha, Anup
AU - Shetty, Disha
AU - Nayak, Usha Y.
N1 - Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021/6
Y1 - 2021/6
N2 - Lymphatic system is the secondary circulation system of the human body after the systemic circula-tion. Various problems, including the first-pass metabolism through oral administration of medicines, can be resolved by lymphatic targeting. Lymphatic absorption has been explored in detail, and studies reveal the improved bioavailability of medicines. In the case of cancer, AIDS, and various other health problems, lymphatic targeting has been focused on due to the fact that lymph nodes are involved greatly in tumor metastasis. This article reviews lymphatic absorption and its exploration in the treatment of various health problems. The physiology of the lymphatic system, the mechanisms of absorption, and the various formulation systems suitable for lymphatic absorption have been discussed. Some recent novel approaches like hydrodynamically driven device (HDD) and carbon nanotubes for lymphatic delivery have also been appraised.
AB - Lymphatic system is the secondary circulation system of the human body after the systemic circula-tion. Various problems, including the first-pass metabolism through oral administration of medicines, can be resolved by lymphatic targeting. Lymphatic absorption has been explored in detail, and studies reveal the improved bioavailability of medicines. In the case of cancer, AIDS, and various other health problems, lymphatic targeting has been focused on due to the fact that lymph nodes are involved greatly in tumor metastasis. This article reviews lymphatic absorption and its exploration in the treatment of various health problems. The physiology of the lymphatic system, the mechanisms of absorption, and the various formulation systems suitable for lymphatic absorption have been discussed. Some recent novel approaches like hydrodynamically driven device (HDD) and carbon nanotubes for lymphatic delivery have also been appraised.
UR - http://www.scopus.com/inward/record.url?scp=85107032845&partnerID=8YFLogxK
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U2 - 10.2174/1381612826999201203214247
DO - 10.2174/1381612826999201203214247
M3 - Review article
C2 - 33272166
AN - SCOPUS:85107032845
SN - 1381-6128
VL - 27
SP - 1992
EP - 1998
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 17
ER -
