TY - JOUR
T1 - Marine microbial metabolites
T2 - A new wave of drugs for combating antimicrobial resistance
AU - Earny, Venkat Abhiram
AU - Kamath, Venkatesh
AU - Muralidharan, Anuraag
AU - Vandana, K. E.
AU - Khera, Kanav
N1 - Funding Information:
The authors are thankful to Manipal Centre for Infectious Diseases (MAC ID), MAHE and Manipal College of Pharmaceutical Sciences, MAHE for their support and assistance.
Publisher Copyright:
© RJPT All right reserved.
PY - 2021/4
Y1 - 2021/4
N2 - The steady increase in the emergence of multidrug-resistant bacteria amongst medical centers, environment, animals, and food is of major concern for health care professionals. Most of the currently used mainline antibacterial drugs were discovered during the golden era of antibiotic discovery (1950-60). During this period, many natural, semi-synthetic, and synthetic molecules were screened for their antimicrobial potential against a spectrum of clinical pathogens. Nevertheless, there was a gap of forty long years until the release of a newer class of antibiotics in the market. It is very vital to develop an integrated approach to combat antimicrobial resistance. There has been a paradigm shift in the field of marine drug discovery in the last two decades. Bioactive metabolites derived from the marine ecosystem are known to exhibit a wide array of pharmacological activity than the terrestrial source. Among all marine organisms, secondary metabolites derived from microbes are the most underexplored natural source. Screening of marine microbes for various antimicrobial molecules has become a noteworthy trend in marine drug discovery and provides a ray of hope for combating antimicrobial resistance.
AB - The steady increase in the emergence of multidrug-resistant bacteria amongst medical centers, environment, animals, and food is of major concern for health care professionals. Most of the currently used mainline antibacterial drugs were discovered during the golden era of antibiotic discovery (1950-60). During this period, many natural, semi-synthetic, and synthetic molecules were screened for their antimicrobial potential against a spectrum of clinical pathogens. Nevertheless, there was a gap of forty long years until the release of a newer class of antibiotics in the market. It is very vital to develop an integrated approach to combat antimicrobial resistance. There has been a paradigm shift in the field of marine drug discovery in the last two decades. Bioactive metabolites derived from the marine ecosystem are known to exhibit a wide array of pharmacological activity than the terrestrial source. Among all marine organisms, secondary metabolites derived from microbes are the most underexplored natural source. Screening of marine microbes for various antimicrobial molecules has become a noteworthy trend in marine drug discovery and provides a ray of hope for combating antimicrobial resistance.
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U2 - 10.52711/0974-360X.2021.00414
DO - 10.52711/0974-360X.2021.00414
M3 - Review article
AN - SCOPUS:85108259888
SN - 0974-3618
VL - 14
SP - 2348
EP - 2352
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 4
ER -