TY - JOUR
T1 - Mast cell stabilizing effects of Sphaeranthus indicus
AU - Mathew, J.E.
AU - Srinivasan, K.K.
AU - Dinakaran, V.
AU - Joseph, A.
N1 - Cited By :15
Export Date: 10 November 2017
CODEN: JOETD
Correspondence Address: Mathew, J.E.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal, 576 104 Karnataka, India; email: [email protected]
Chemicals/CAS: acetic acid ethyl ester, 141-78-6; alcohol, 64-17-5; ketotifen fumarate, 34580-14-8; Plant Extracts; p-Methoxy-N-methylphenethylamine, 4091-50-3
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PY - 2009
Y1 - 2009
N2 - Aim of the study: We investigated the effects of Sphaeranthus indicus on mast cell stabilizing activity to provide scientific basis for the clinical use of S. indicus. Materials and methods: The protective effect of different extracts of whole plant of S. indicus against compound 48/80 and sheep serum induced mast cell degranulation was evaluated. Results: Ethanol extract of S. indicus at the doses of 150 mg/kg and 300 mg/kg and ethyl acetate extract at the dose of 100 mg/kg, 150 mg/kg and 300 mg/kg showed slightly better protection of mast cell degranulation (77-86%) than the standard drug ketotifen (75%) in the sheep serum model. These extracts also showed better mast cell stabilizing activity (77-88%) than the standard drug (69%) when peritoneal mast cells are treated with compound 48/80. Conclusion: These results suggest that S. indicus has potent mast cell stabilizing effects thereby inhibiting mediator release from mast cells. © 2009 Elsevier Ireland Ltd. All rights reserved.
AB - Aim of the study: We investigated the effects of Sphaeranthus indicus on mast cell stabilizing activity to provide scientific basis for the clinical use of S. indicus. Materials and methods: The protective effect of different extracts of whole plant of S. indicus against compound 48/80 and sheep serum induced mast cell degranulation was evaluated. Results: Ethanol extract of S. indicus at the doses of 150 mg/kg and 300 mg/kg and ethyl acetate extract at the dose of 100 mg/kg, 150 mg/kg and 300 mg/kg showed slightly better protection of mast cell degranulation (77-86%) than the standard drug ketotifen (75%) in the sheep serum model. These extracts also showed better mast cell stabilizing activity (77-88%) than the standard drug (69%) when peritoneal mast cells are treated with compound 48/80. Conclusion: These results suggest that S. indicus has potent mast cell stabilizing effects thereby inhibiting mediator release from mast cells. © 2009 Elsevier Ireland Ltd. All rights reserved.
U2 - 10.1016/j.jep.2009.01.015
DO - 10.1016/j.jep.2009.01.015
M3 - Article
SN - 0378-8741
VL - 122
SP - 394
EP - 396
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2
ER -