TY - JOUR
T1 - Maternal sepsis in the era of genomic medicine
AU - Kouskouti, C.
AU - Evangelatos, N.
AU - Brand, A.
AU - Kainer, F.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Purpose: Maternal sepsis remains one of the leading causes of direct and indirect maternal mortality both in high- and low-income environments. In the last two decades, systems biology approaches, based on ‘-omics’ technologies, have started revolutionizing the diagnosis and management of the septic syndrome. The scope of this narrative review is to present an overview of the basic ‘-omics’ technologies, exemplified by cases relevant to maternal sepsis. Methods: Narrative review of the new ‘-omics’ technologies based on a detailed review of the literature. Results: After presenting the main ‘omics’ technologies, we discuss their limitations and the need for integrated approaches that encompass research efforts across multiple ‘-omics’ layers in the ‘-omics’ cascade between the genome and the phenome. Conclusions: Systems biology approaches are revolutionizing the research landscape in maternal sepsis. There is a need for increased awareness, from the side of health practitioners, as a requirement for the effective implementation of the new technologies in the research and clinical practice in maternal sepsis.
AB - Purpose: Maternal sepsis remains one of the leading causes of direct and indirect maternal mortality both in high- and low-income environments. In the last two decades, systems biology approaches, based on ‘-omics’ technologies, have started revolutionizing the diagnosis and management of the septic syndrome. The scope of this narrative review is to present an overview of the basic ‘-omics’ technologies, exemplified by cases relevant to maternal sepsis. Methods: Narrative review of the new ‘-omics’ technologies based on a detailed review of the literature. Results: After presenting the main ‘omics’ technologies, we discuss their limitations and the need for integrated approaches that encompass research efforts across multiple ‘-omics’ layers in the ‘-omics’ cascade between the genome and the phenome. Conclusions: Systems biology approaches are revolutionizing the research landscape in maternal sepsis. There is a need for increased awareness, from the side of health practitioners, as a requirement for the effective implementation of the new technologies in the research and clinical practice in maternal sepsis.
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U2 - 10.1007/s00404-017-4584-5
DO - 10.1007/s00404-017-4584-5
M3 - Article
AN - SCOPUS:85032812828
SN - 0932-0067
SP - 1
EP - 12
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
ER -