May-Thurner syndrome, an unprovoked form of deep vein thrombosis (DVT), should be kept in mind in case of DVT with no predisposing factors. We present a case of a 37-year-old male with DVT of left lower limb due to May-Thurner syndrome, treated with anticoagulants with a plan of left common iliac vein (LCIV) stenting and inferior vena cava (IVC) filter later. Venous duplex scan showed features suggestive of May-Thurner syndrome. Hence, we proceeded for CT abdominal aortogram with bilateral lower limb angiogram, which confirmed the above findings. Management of May-Thurner syndrome is a stepwise approach, with initial anticoagulation for dissolution of the thrombus followed by endovenous stenting of the LCIV and concomitant IVC filter.
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