Mechanistic study of oxidation of sulfacetamide by diperiodatocuprate(III) in aqueous alkaline medium

P. N. Naik; S. D. Kulkarni; S. A. Chimatadar; S. T. Nandibewoor

Mechanistic study of oxidation of sulfacetamide by diperiodatocuprate(III) in aqueous alkaline medium

P. N. Naik, S. D. Kulkarni, S. A. Chimatadar, S. T. Nandibewoor

Department of Atomic and Molecular Physics, Manipal

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The oxidation of sulfacetamide, a sulfonamide drug, by alkaline diperiodatocuprate(III) has been studied at 298 K and at constant ionic strength. The reaction is first order in diperiodatocuprate(III) and has less than unit order in sulfacetamide concentration. The rate constants increase with increase in alkali concentration and decrease with increase in periodate concentration. A mechanism has been proposed wherein monoperiodatocuprate(III) is the active species. The reaction constants involved in the different steps of the mechanism and the activation parameters for the slow step have been computed.

Original language	English
Pages (from-to)	1666-1670
Number of pages	5
Journal	Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry
Volume	47
Issue number	11
Publication status	Published - 01-11-2008

All Science Journal Classification (ASJC) codes

Physical and Theoretical Chemistry
Inorganic Chemistry

Cite this

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title = "Mechanistic study of oxidation of sulfacetamide by diperiodatocuprate(III) in aqueous alkaline medium",

abstract = "The oxidation of sulfacetamide, a sulfonamide drug, by alkaline diperiodatocuprate(III) has been studied at 298 K and at constant ionic strength. The reaction is first order in diperiodatocuprate(III) and has less than unit order in sulfacetamide concentration. The rate constants increase with increase in alkali concentration and decrease with increase in periodate concentration. A mechanism has been proposed wherein monoperiodatocuprate(III) is the active species. The reaction constants involved in the different steps of the mechanism and the activation parameters for the slow step have been computed.",

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Mechanistic study of oxidation of sulfacetamide by diperiodatocuprate(III) in aqueous alkaline medium. / Naik, P. N.; Kulkarni, S. D.; Chimatadar, S. A. et al.
In: Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, Vol. 47, No. 11, 01.11.2008, p. 1666-1670.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Mechanistic study of oxidation of sulfacetamide by diperiodatocuprate(III) in aqueous alkaline medium

AU - Naik, P. N.

AU - Kulkarni, S. D.

AU - Chimatadar, S. A.

AU - Nandibewoor, S. T.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - The oxidation of sulfacetamide, a sulfonamide drug, by alkaline diperiodatocuprate(III) has been studied at 298 K and at constant ionic strength. The reaction is first order in diperiodatocuprate(III) and has less than unit order in sulfacetamide concentration. The rate constants increase with increase in alkali concentration and decrease with increase in periodate concentration. A mechanism has been proposed wherein monoperiodatocuprate(III) is the active species. The reaction constants involved in the different steps of the mechanism and the activation parameters for the slow step have been computed.

AB - The oxidation of sulfacetamide, a sulfonamide drug, by alkaline diperiodatocuprate(III) has been studied at 298 K and at constant ionic strength. The reaction is first order in diperiodatocuprate(III) and has less than unit order in sulfacetamide concentration. The rate constants increase with increase in alkali concentration and decrease with increase in periodate concentration. A mechanism has been proposed wherein monoperiodatocuprate(III) is the active species. The reaction constants involved in the different steps of the mechanism and the activation parameters for the slow step have been computed.

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M3 - Article

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SN - 0376-4710

VL - 47

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EP - 1670

JO - Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry

JF - Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry

IS - 11

ER -

Mechanistic study of oxidation of sulfacetamide by diperiodatocuprate(III) in aqueous alkaline medium

Abstract

All Science Journal Classification (ASJC) codes

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