Medical abortion by Mifepristone with sublingual vs vaginal misoprostol: A randomised comparative trial

Jyothi Shetty, T. Shanmugapriya, Asha Kamath

Research output: Contribution to journalArticlepeer-review


To compare the success and side-effects between the sublingual and the vaginal administration of Misoprostol for induced abortion in women treated initially with Mifepristone. We administered 200 mg of Mifepristone to 117 women who requested termination of pregnancy of under-9 weeks. Forty-eight hours later they were randomised into two groups. Fifty-eight women received two doses of Misoprostol sublingually 3 hrs apart, while 59 women received Misoprostol 800 meg vaginally. They were observed for 3 hrs and returned on 15th day for final assessment. Complete abortion occurred in 96.5% (95% Cl: 91-100) of the women in the sublingual group and 96.6% (95% Cl: 91-100) in the vaginal group. This regimen resulted in complete abortion in all women (100%) when it was administered before 7 weeks gestation. The median induction-to-abortion interval was shorter in women in the sublingual group compared to the vaginal group (P <0.001). Women in the sublingual group experienced more diarrhoea (P = 0.005), chills (P <0.001) and fever (P = 0.001). Two doses of sublingual Misoprostol administered after Mifepristone is an effective alternative route to the standard vaginal administration for medical abortion.

Original languageEnglish
Pages (from-to)221-228
Number of pages8
JournalHealth and Population: Perspectives and Issues
Issue number4
Publication statusPublished - 10-2008

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Health(social science)
  • Public Health, Environmental and Occupational Health


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