Metal-Based Carriers for Targeting Lymphatic System

Lymphatic drug delivery systems play a crucial role in enhancing mucosal immunity and chemotherapy efficacy and facilitating oral absorption. Despite the intricate nature of the lymphatic system, targeting drug delivery is vital for com bating cancer metastasis and overcoming limitations associated with traditional chemotherapy. The development of microparticulate systems aims to precisely target regional lymph nodes, offering potential benefits such as improved drug absorption and reduced adverse effects. Metallic nanoparticles serve as versatile drug delivery systems for various therapeutics. These nanoparticles, including copper, zinc and gold nanoparticles, exhibit adjustable optical parameters and can be easily functionalized with targeted agents, enabling targeted delivery and prolonged drug circulation time. Metal-based nanomaterials such as metal-organic frameworks, metal nanoparticles, metal sulfide nanoparticles, metal oxide nanoparticles, and doped metal/oxide nanoparticles have been widespread due to their intriguing properties and diverse applications. Advanced imaging techniques utilizing magnetic nanoparticles contribute to accurate lymphatic staging without invasive biopsies. Both passive and active therapeutic approaches targeting the lymphatic system show promise in improving drug delivery. This chapter will delve into the various metallic nanoparticles, their fabrication methods and their roles in targeting and imaging the lymphatic system.