TY - JOUR
T1 - Method development and validation for the estimation of Ticargrelor in bulk and comparison with other published methods
AU - Shane, Nazare Lobo John
AU - Chamle, Ashish Hanumantrao
AU - Vasantharaju, S. G.
AU - Pai, Aravind
AU - Muddukrishna, B. S.
PY - 2016
Y1 - 2016
N2 - The following article consist of highly sensitive and easy RP-HPLC method to estimate Ticagrelor in bulk. Ticagrelor was separated using Shimadzu LC-20-AD with auto sampler and PDA/UV detector. The separation was achieved using a C18 Vydac Monomeric 120A (5.0 micron, 250 x 4.6mm) column. Acetonitrile: Water Milli Q (60:40 v/v) at a flow rate of 1.0 ml/min was used as the mobile phase. The method was linear having line equation f(x)=1.90442e-005*x-0.302059 with correlation coefficient (R2) of 0.997. The method was precise having RSD as 0.27% (intraday precision). The LOD & LOQ were 0.083μg/mL and 0.25μg/mL respectively. The developed method was validated for precision, linearity, system suitability and robustness; hence proves that it is highly applicable to estimate Ticagrelor in day to day analysis.
AB - The following article consist of highly sensitive and easy RP-HPLC method to estimate Ticagrelor in bulk. Ticagrelor was separated using Shimadzu LC-20-AD with auto sampler and PDA/UV detector. The separation was achieved using a C18 Vydac Monomeric 120A (5.0 micron, 250 x 4.6mm) column. Acetonitrile: Water Milli Q (60:40 v/v) at a flow rate of 1.0 ml/min was used as the mobile phase. The method was linear having line equation f(x)=1.90442e-005*x-0.302059 with correlation coefficient (R2) of 0.997. The method was precise having RSD as 0.27% (intraday precision). The LOD & LOQ were 0.083μg/mL and 0.25μg/mL respectively. The developed method was validated for precision, linearity, system suitability and robustness; hence proves that it is highly applicable to estimate Ticagrelor in day to day analysis.
UR - http://www.scopus.com/inward/record.url?scp=85013277135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85013277135&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85013277135
SN - 0975-8542
VL - 8
SP - 1
EP - 6
JO - Journal of Global Pharma Technology
JF - Journal of Global Pharma Technology
IS - 12
ER -