TY - JOUR
T1 - Methylenetetrahydrofolate Reductase Gene Polymorphism as a Risk Factor for Coronary Artery Disease
AU - Sowndarya, K.
AU - Manjrekar, Poornima A.
AU - Shenoy, Ramya
AU - Hegde, Anupama
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Association of Clinical Biochemists of India.
PY - 2023
Y1 - 2023
N2 - Hyperhomocysteinemia (HHcy) is one of the factors contributing to the pathogenesis of coronary artery disease (CAD). Besides nutritional deficiency disorders, genetic polymorphism predominantly related to point mutation in the gene coding for Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the metabolism methionine–homocysteine (Hcy) has been implicated in HHcy. PubMed survey related to MTHFR gene polymorphism in CAD retrieved 143 articles from which 20 were selected in which MTHFR gene polymorphism and Hcy were estimated. The selected studies had estimated either MTHFRC677T or A1298C or both. All the studies detected presence of MTHFRC677T in CAD. Hcy levels were found to range from normal to HHcy with debatable association to CAD.
AB - Hyperhomocysteinemia (HHcy) is one of the factors contributing to the pathogenesis of coronary artery disease (CAD). Besides nutritional deficiency disorders, genetic polymorphism predominantly related to point mutation in the gene coding for Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the metabolism methionine–homocysteine (Hcy) has been implicated in HHcy. PubMed survey related to MTHFR gene polymorphism in CAD retrieved 143 articles from which 20 were selected in which MTHFR gene polymorphism and Hcy were estimated. The selected studies had estimated either MTHFRC677T or A1298C or both. All the studies detected presence of MTHFRC677T in CAD. Hcy levels were found to range from normal to HHcy with debatable association to CAD.
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U2 - 10.1007/s12291-023-01162-z
DO - 10.1007/s12291-023-01162-z
M3 - Review article
AN - SCOPUS:85177701822
SN - 0970-1915
JO - Indian Journal of Clinical Biochemistry
JF - Indian Journal of Clinical Biochemistry
ER -