MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology

Karthik Gourishetti; Vignesh Balaji Easwaran; Youssef Mostakim; K. Sreedhara Ranganath Pai; Deepak Bhere

doi:10.3390/biology12070922

MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology

Karthik Gourishetti
, Vignesh Balaji Easwaran
, Youssef Mostakim
, K. Sreedhara Ranganath Pai
, Deepak Bhere^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

MicroRNA (miR) are a class of small non-coding RNA that are involved in post-transcriptional gene regulation. Altered expression of miR has been associated with several pathological conditions. MicroRNA-124 (miR-124) is an abundantly expressed miR in the brain as well as the thymus, lymph nodes, bone marrow, and peripheral blood mono-nuclear cells. It plays a key role in the regulation of the host immune system. Emerging studies show that dysregulated expression of miR-124 is a hallmark in several cancer types and it has been attributed to the progression of these malignancies. In this review, we present a comprehensive summary of the role of miR-124 as a promising therapeutic gateway in oncology.

Original language	English
Article number	922
Journal	Biology
Volume	12
Issue number	7
DOIs	https://doi.org/10.3390/biology12070922
Publication status	Published - 07-2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences

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10.3390/biology12070922

Cite this

@article{8752b8eb3ddf45bbb93c6e85899040f3,

title = "MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology",

abstract = "MicroRNA (miR) are a class of small non-coding RNA that are involved in post-transcriptional gene regulation. Altered expression of miR has been associated with several pathological conditions. MicroRNA-124 (miR-124) is an abundantly expressed miR in the brain as well as the thymus, lymph nodes, bone marrow, and peripheral blood mono-nuclear cells. It plays a key role in the regulation of the host immune system. Emerging studies show that dysregulated expression of miR-124 is a hallmark in several cancer types and it has been attributed to the progression of these malignancies. In this review, we present a comprehensive summary of the role of miR-124 as a promising therapeutic gateway in oncology.",

author = "Karthik Gourishetti and \{Balaji Easwaran\}, Vignesh and Youssef Mostakim and \{Ranganath Pai\}, \{K. Sreedhara\} and Deepak Bhere",

note = "Funding Information: This work was supported by the National Institutes of Health—National Cancer Institute grant R00 CA245030 (D.B.). Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jul,

doi = "10.3390/biology12070922",

language = "English",

volume = "12",

journal = "Biology",

issn = "2079-7737",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

TY - JOUR

T1 - MicroRNA (miR)-124

T2 - A Promising Therapeutic Gateway for Oncology

AU - Gourishetti, Karthik

AU - Balaji Easwaran, Vignesh

AU - Mostakim, Youssef

AU - Ranganath Pai, K. Sreedhara

AU - Bhere, Deepak

PY - 2023/7

Y1 - 2023/7

N2 - MicroRNA (miR) are a class of small non-coding RNA that are involved in post-transcriptional gene regulation. Altered expression of miR has been associated with several pathological conditions. MicroRNA-124 (miR-124) is an abundantly expressed miR in the brain as well as the thymus, lymph nodes, bone marrow, and peripheral blood mono-nuclear cells. It plays a key role in the regulation of the host immune system. Emerging studies show that dysregulated expression of miR-124 is a hallmark in several cancer types and it has been attributed to the progression of these malignancies. In this review, we present a comprehensive summary of the role of miR-124 as a promising therapeutic gateway in oncology.

AB - MicroRNA (miR) are a class of small non-coding RNA that are involved in post-transcriptional gene regulation. Altered expression of miR has been associated with several pathological conditions. MicroRNA-124 (miR-124) is an abundantly expressed miR in the brain as well as the thymus, lymph nodes, bone marrow, and peripheral blood mono-nuclear cells. It plays a key role in the regulation of the host immune system. Emerging studies show that dysregulated expression of miR-124 is a hallmark in several cancer types and it has been attributed to the progression of these malignancies. In this review, we present a comprehensive summary of the role of miR-124 as a promising therapeutic gateway in oncology.

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UR - https://www.scopus.com/pages/publications/85166324375#tab=citedBy

U2 - 10.3390/biology12070922

DO - 10.3390/biology12070922

M3 - Review article

AN - SCOPUS:85166324375

SN - 2079-7737

VL - 12

JO - Biology

JF - Biology

IS - 7

M1 - 922

ER -

MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology

Abstract

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