TY - JOUR
T1 - Microwave-assisted and conventional synthesis of benzothieno [3,2-e] [1,3,4] triazolo[4,3-c]pyrimidines
T2 - A comparative study
AU - Gaonkar, Santhosh L.
AU - Ahn, Chuljin
AU - Princia,
AU - Shetty, Nitinkumar S.
PY - 2014/8/20
Y1 - 2014/8/20
N2 - Benzothieno[2,3-d]pyrimidines (2,3,4) and benzothieno[3,2-e][1,3,4] triazolo[4,3-c] pyrimidines (5a-c) were synthesized from the precursor 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 by employing the conventional method as well as the microwave irradiation technique. The precursor 2-amino-3-cyanothiophene analogue 1 was synthesized by employing the well-known Gewald reaction. In the present work it has been found that the microwave supported syntheses are more efficient than the conventional classical heating methods. The structures of all the compounds were ascertained by spectral and analytical data.
AB - Benzothieno[2,3-d]pyrimidines (2,3,4) and benzothieno[3,2-e][1,3,4] triazolo[4,3-c] pyrimidines (5a-c) were synthesized from the precursor 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 by employing the conventional method as well as the microwave irradiation technique. The precursor 2-amino-3-cyanothiophene analogue 1 was synthesized by employing the well-known Gewald reaction. In the present work it has been found that the microwave supported syntheses are more efficient than the conventional classical heating methods. The structures of all the compounds were ascertained by spectral and analytical data.
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U2 - 10.5012/jkcs.2014.58.4.388
DO - 10.5012/jkcs.2014.58.4.388
M3 - Article
AN - SCOPUS:84905169781
SN - 1017-2548
VL - 58
SP - 388
EP - 392
JO - Journal of the Korean Chemical Society
JF - Journal of the Korean Chemical Society
IS - 4
ER -