Microwave-assisted solvent-free synthesis of N-alkyl benzotriazole derivatives: Antimicrobial studies

Raghu Ningegowda, C. V. Kavitha, B. S. Priya, S. L. Gaonkar, M. V. Tejesvi, K. S. Rangappa, S. Nanjunda Swamy

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


To elucidate further our structural activity relation on the chemistry and antimicrobial activity, a series of novel N-alkylated benzotriazole derivatives bearing pharmaceutically important substituted biphenyl and benzyl halides were synthesized. The synthesized compounds were characterized and tested for in vitro antimicrobial activities by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms. The synthesis has been carried out using microwave irradiation method with solvent and without solvent. The obtained results showed high yields. Interestingly, compounds 2a and 2b showed a two fold increased antibacterial activity than the standard drug tested and the compounds 2d and 2e showed potent antifungal activity than the standard drug tested.

Original languageEnglish
Pages (from-to)502-507
Number of pages6
JournalLetters in Drug Design and Discovery
Issue number7
Publication statusPublished - 10-2009

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Pharmaceutical Science


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