Microwave-assisted synthesis of the antihyperglycemic drug rosiglitazone

Santosh L. Gaonkar; Hiroki Shimizu

doi:10.1016/j.tet.2010.03.006

Microwave-assisted synthesis of the antihyperglycemic drug rosiglitazone

Santosh L. Gaonkar
, Hiroki Shimizu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

We developed a simple, rapid, high yielding, and environmentally benign microwave assisted total synthesis of rosiglitazone, an antihyperglycemic agent for diabetes mellitus Type II. We used microwave heating successfully to improve reactions in four of six steps and obtain quicker and higher yields. In addition, all intermediates were isolated in good yields with crystallizations only and did not require chromatographic separations.

Original language	English
Pages (from-to)	3314-3317
Number of pages	4
Journal	Tetrahedron
Volume	66
Issue number	18
DOIs	https://doi.org/10.1016/j.tet.2010.03.006
Publication status	Published - 01-05-2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/j.tet.2010.03.006

Cite this

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abstract = "We developed a simple, rapid, high yielding, and environmentally benign microwave assisted total synthesis of rosiglitazone, an antihyperglycemic agent for diabetes mellitus Type II. We used microwave heating successfully to improve reactions in four of six steps and obtain quicker and higher yields. In addition, all intermediates were isolated in good yields with crystallizations only and did not require chromatographic separations.",

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AU - Shimizu, Hiroki

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N2 - We developed a simple, rapid, high yielding, and environmentally benign microwave assisted total synthesis of rosiglitazone, an antihyperglycemic agent for diabetes mellitus Type II. We used microwave heating successfully to improve reactions in four of six steps and obtain quicker and higher yields. In addition, all intermediates were isolated in good yields with crystallizations only and did not require chromatographic separations.

AB - We developed a simple, rapid, high yielding, and environmentally benign microwave assisted total synthesis of rosiglitazone, an antihyperglycemic agent for diabetes mellitus Type II. We used microwave heating successfully to improve reactions in four of six steps and obtain quicker and higher yields. In addition, all intermediates were isolated in good yields with crystallizations only and did not require chromatographic separations.

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Microwave-assisted synthesis of the antihyperglycemic drug rosiglitazone

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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