Models for assessing the role of selenoproteins in health

Mohamed E. Moustafa; Easwari Kumaraswamy; Nianxin Zhong; Mahadev Rao; Bradley A. Carlson; Dolph L. Hatfield

doi:10.1093/jn/133.7.2494s

Models for assessing the role of selenoproteins in health

Mohamed E. Moustafa
, Easwari Kumaraswamy
, Nianxin Zhong
, Mahadev Rao
, Bradley A. Carlson
, Dolph L. Hatfield^*

^*Corresponding author for this work

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Two model systems for examining the role of selenoproteins in health are discussed. One utilizes transgenic mice that carry mutant selenocysteine (Sec) tRNA transgenes that result in the reduction of selenoprotein expression in a protein- and tissue-specific manner. The other utilizes loxP-Cre technology to selectively remove the Sec tRNA gene in mammary epithelium that results in the reduction of only certain selenoproteins in this tissue. Both approaches provide important tools for examining the role of selenoproteins in health.

Original language	English
Pages (from-to)	2494S-2496S
Journal	Journal of Nutrition
Volume	133
Issue number	7 SUPPL.
DOIs	https://doi.org/10.1093/jn/133.7.2494s
Publication status	Published - 01-07-2003

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Nutrition and Dietetics

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AU - Moustafa, Mohamed E.

AU - Kumaraswamy, Easwari

AU - Zhong, Nianxin

AU - Rao, Mahadev

AU - Carlson, Bradley A.

AU - Hatfield, Dolph L.

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AB - Two model systems for examining the role of selenoproteins in health are discussed. One utilizes transgenic mice that carry mutant selenocysteine (Sec) tRNA transgenes that result in the reduction of selenoprotein expression in a protein- and tissue-specific manner. The other utilizes loxP-Cre technology to selectively remove the Sec tRNA gene in mammary epithelium that results in the reduction of only certain selenoproteins in this tissue. Both approaches provide important tools for examining the role of selenoproteins in health.

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Models for assessing the role of selenoproteins in health

Abstract

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