TY - JOUR
T1 - Modified pectins for colon-specific drug delivery
AU - Muvva, Aneesh
AU - Chacko, Indhu Annie
AU - Ghate, Vivek
AU - Lewis, Shaila Angela
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Treatment of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome and colonic cancer by targeting drug to the colon is a viable approach. Due to gastric degradation of drugs, proteins and peptides, only minimum amount of drug gets absorbed when administered orally and shows little therapeutic activity. Hence the strategy of delivering drugs to colon known as colon targeted drug delivery evolved. Pectin a naturally occurring biodegradable polysaccharide has gained importance as a carrier for colon-specific delivery attributed to swelling nature as well as the ability to resist gastric degradation. This review describes the chemistry of pectin, mechanism of action and various novel modified pectin formulations aimed at targeting the colon.
AB - Treatment of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome and colonic cancer by targeting drug to the colon is a viable approach. Due to gastric degradation of drugs, proteins and peptides, only minimum amount of drug gets absorbed when administered orally and shows little therapeutic activity. Hence the strategy of delivering drugs to colon known as colon targeted drug delivery evolved. Pectin a naturally occurring biodegradable polysaccharide has gained importance as a carrier for colon-specific delivery attributed to swelling nature as well as the ability to resist gastric degradation. This review describes the chemistry of pectin, mechanism of action and various novel modified pectin formulations aimed at targeting the colon.
UR - http://www.scopus.com/inward/record.url?scp=85085949538&partnerID=8YFLogxK
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U2 - 10.5530/ijper.54.2s.57
DO - 10.5530/ijper.54.2s.57
M3 - Review article
AN - SCOPUS:85085949538
SN - 0019-5464
VL - 54
SP - S12-S18
JO - Indian Journal of Pharmaceutical Education and Research
JF - Indian Journal of Pharmaceutical Education and Research
IS - 2
ER -