Modulation of gut microbiota: An emerging consequence in neonatal sepsis

Faiza Iqbal; Leslie Edward S. Lewis; N. Siva; Vandana K E; Jayashree Purkayastha; Padmaja A. Shenoy

doi:10.1016/j.cegh.2023.101245

Modulation of gut microbiota: An emerging consequence in neonatal sepsis

Faiza Iqbal
, Leslie Edward S. Lewis^*
, N. Siva
, Vandana K E
, Jayashree Purkayastha
, Padmaja A. Shenoy

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

Introduction: Billions of microorganisms reside in gut altering its homeostasis and leading to various diseases. The initial days of life are crucial for developing gut flora that helps in gut maturation and neonatal health. This review summarizes the evidence on seeding of neonatal gut microbiota, modulation of gut microbiota in neonatal sepsis, antimicrobial resistance, and role of probiotics or other therapies to re-establish altered microbiota. Conclusion: Gut microbiota regulates host physiological homeostasis mediators, including the gut barrier function, and disease susceptibility pathways. Maintenance or restoration of microbiota and metabolite composition may be a therapeutic or preventative target against critical illness.

Original language	English
Article number	101245
Journal	Clinical Epidemiology and Global Health
Volume	20
DOIs	https://doi.org/10.1016/j.cegh.2023.101245
Publication status	Published - 01-03-2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Epidemiology
Public Health, Environmental and Occupational Health
Microbiology (medical)
Infectious Diseases

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10.1016/j.cegh.2023.101245

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@article{b3abdd1ec17047449fa4b7cf72b08bb6,

title = "Modulation of gut microbiota: An emerging consequence in neonatal sepsis",

abstract = "Introduction: Billions of microorganisms reside in gut altering its homeostasis and leading to various diseases. The initial days of life are crucial for developing gut flora that helps in gut maturation and neonatal health. This review summarizes the evidence on seeding of neonatal gut microbiota, modulation of gut microbiota in neonatal sepsis, antimicrobial resistance, and role of probiotics or other therapies to re-establish altered microbiota. Conclusion: Gut microbiota regulates host physiological homeostasis mediators, including the gut barrier function, and disease susceptibility pathways. Maintenance or restoration of microbiota and metabolite composition may be a therapeutic or preventative target against critical illness.",

author = "Faiza Iqbal and Lewis, \{Leslie Edward S.\} and N. Siva and \{K E\}, Vandana and Jayashree Purkayastha and Shenoy, \{Padmaja A.\}",

note = "Funding Information: The authors would like to acknowledge Kasturba Medical College and Manipal Academy of Higher Education for providing technical support. Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = mar,

day = "1",

doi = "10.1016/j.cegh.2023.101245",

language = "English",

volume = "20",

journal = "Clinical Epidemiology and Global Health",

issn = "2213-3984",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Modulation of gut microbiota

T2 - An emerging consequence in neonatal sepsis

AU - Iqbal, Faiza

AU - Lewis, Leslie Edward S.

AU - Siva, N.

AU - K E, Vandana

AU - Purkayastha, Jayashree

AU - Shenoy, Padmaja A.

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Introduction: Billions of microorganisms reside in gut altering its homeostasis and leading to various diseases. The initial days of life are crucial for developing gut flora that helps in gut maturation and neonatal health. This review summarizes the evidence on seeding of neonatal gut microbiota, modulation of gut microbiota in neonatal sepsis, antimicrobial resistance, and role of probiotics or other therapies to re-establish altered microbiota. Conclusion: Gut microbiota regulates host physiological homeostasis mediators, including the gut barrier function, and disease susceptibility pathways. Maintenance or restoration of microbiota and metabolite composition may be a therapeutic or preventative target against critical illness.

AB - Introduction: Billions of microorganisms reside in gut altering its homeostasis and leading to various diseases. The initial days of life are crucial for developing gut flora that helps in gut maturation and neonatal health. This review summarizes the evidence on seeding of neonatal gut microbiota, modulation of gut microbiota in neonatal sepsis, antimicrobial resistance, and role of probiotics or other therapies to re-establish altered microbiota. Conclusion: Gut microbiota regulates host physiological homeostasis mediators, including the gut barrier function, and disease susceptibility pathways. Maintenance or restoration of microbiota and metabolite composition may be a therapeutic or preventative target against critical illness.

UR - https://www.scopus.com/pages/publications/85147353526

UR - https://www.scopus.com/pages/publications/85147353526#tab=citedBy

U2 - 10.1016/j.cegh.2023.101245

DO - 10.1016/j.cegh.2023.101245

M3 - Review article

AN - SCOPUS:85147353526

SN - 2213-3984

VL - 20

JO - Clinical Epidemiology and Global Health

JF - Clinical Epidemiology and Global Health

M1 - 101245

ER -

Modulation of gut microbiota: An emerging consequence in neonatal sepsis

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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